Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma

Table 4

Cox regression models of association between PCLND and LRR.

	Model 1		Model 2		Model 3
	Hazard ratio	value	Hazard ratio	value	Hazard ratio	value
PCLND	0.911 (0.214–3.885)	0.900	0.873 (0.204–3.734)	0.855	0.876 (0.177–4.334)	0.872
Age	—	—	0.976 (0.943–1.011)	0.175	0.990 (0.956–1.026)	0.596
Gender	—	—	0.854 (0.339–2.1507)	0.738	1.000 (0.391–2.563)	0.999
Surgery
TT	—	—	—	—	1
ST	—	—	—	—	0.601 (0.233–1.550)	0.292
LT	—	—	—	—	0.839 (0.244–2.879)	0.780
Diameter	—	—	—	—	3.400 (0.607–19.037)	0.164
Multifocality	—	—	—	—	0.549 (0.179–1.680)	0.293
Capsule invasion	—	—	—	—	0.619 (0.233–1.645)	0.337
ETE	—	—	—	—	1.958 (0.246–15.607)	0.526
Occult central lymph node metastases					2.200 (0.922–5.248)	0.075

PCLND, prophylactic central lymph node dissection; LRR, locoregional recurrence; TT, total thyroidectomy; ST, subtotal thyroidectomy; TL, thyroid lobectomy; ETE, extrathyroidal extension; Model 1, unadjusted model was established by one-on-one association of PCLND and regional recurrence; Model 2, model adjusted for age and sex; Model 3, multivariate model adjusted for all factors (such as age, sex, type of operative procedure, operative complications, tumor size, multifocality, capsule invasion, ETE, and occult central lymph node metastases).