Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1

Figure 1

Cell viability of HepaRG cells following exposure to metformin alone and in combination with RIF or CITCO. (a) HepaRG cells were exposed to vehicle control (a similar volume of DMSO), metformin (MET; 0.5, 1 mM), RIF (20 μM), or metformin in combination with RIF for 24, 48, and 72 h. (b) HepaRG cells were exposed to vehicle control (a similar volume of DMSO), metformin (0.5, 1 mM), CITCO (1 μM), or metformin in combination with CITCO for 24, 48, and 72 h. Cell viability was monitored by CCK8 assay. The data shown are the mean ± SEM (n = 3). (, compared to the control group).

(a)

(b)