Serum Irisin Level Is Positively Associated with Bone Mineral Density in Patients on Maintenance Hemodialysis
Table 1
Clinical characteristics according to different lumbar T-score cutoff points (normal, osteopenia, and osteoporosis) of the 80 hemodialysis patients.
Characteristics
All patients (n = 80)
Normal (n = 51)
Osteopenia (n = 19)
Osteoporosis (n = 10)
Age (years)
66.93 ± 10.27
64.71 ± 10.10
70.11 ± 9.95
72.20 ± 9.00
0.031
Hemodialysis duration (months)
57.66 (23.82–122.34)
56.88 (19.44–114.96)
81.00 (34.44–145.20)
47.58 (15.72–164.61)
0.484
Height (cm)
159.74 ± 8.28
161.80 ± 7.80
156.47 ± 7.18†
155.40 ± 9.63
0.010
Body weight (kg)
64.13 ± 14.55
67.95 ± 14.32
60.41 ± 10.13
51.75 ± 15.15‡
0.002
Body mass index (kg/m2)
24.99 ± 4.66
25.88 ± 4.78
24.64 ± 3.76
21.12 ± 3.77‡
0.010
Lumbar bone mineral density (g/cm2)
0.95 ± 0.20
1.07 ± 0.14
0.80 ± 0.06†
0.65 ± 0.05‡,a
<0.001
Lumbar T-score
−0.51 ± 1.60
0.45 ± 1.10
−1.73 ± 0.44†
−3.03 ± 0.38‡,a
<0.001
Lumbar Z-score
0.57 ± 1.06
1.08 ± 0.76
0.08 ± 0.61†
−1.09 ± 0.87‡,a
<0.001
Systolic blood pressure (mmHg)
136.60 ± 24.37
140.72 ± 24.56
132.16 ± 21.27
124.00 ± 25.36
0.091
Diastolic blood pressure (mmHg)
73.23 ± 13.78
73.35 ± 15.10
71.16 ± 9.67
66.30 ± 11.14
0.124
Albumin (mg/dL)
4.10 (3.90–4.40)
4.10 (3.90–4.40)
4.10 (4.00–4.10)
4.20 (3.68–5.25)
0.630
Blood urea nitrogen (mg/dL)
58.74 ± 14.47
57.71 ± 13.65
61.00 ± 10.11
59.70 ± 16.30
0.687
Creatinine (mg/dL)
9.22 ± 1.79
9.49 ± 1.81
8.78 ± 1.67
8.65 ± 1.98
0.186
Alkaline phosphatase (U/L)
83.86 ± 29.95
78.65 ± 27.50
84.42 ± 29.87
109.40 ± 31.74‡
0.010
Total calcium (mg/dL)
8.96 ± 0.78
8.91 ± 0.77
9.15 ± 0.82
8.96 ± 0.78
0.464
Phosphorus (mg/dL)
4.62 ± 1.21
4.71 ± 1.13
4.67 ± 1.25
4.07 ± 1.54
0.310
Intact parathyroid hormone (pg/mL)
225.72 ± 182.18
208.59 ± 178.27
266.92 ± 185.17
234.84 ± 202.18
0.491
Irisin (ng/mL)
39.99 (12.51–105.84)
54.92 (17.46–161.30)
34.19 (12.99–56.16)†
3.01 (1.52–9.03)‡,a
<0.001
Urea reduction rate
0.73 ± 0.04
0.72 ± 0.04
0.75 ± 0.04†
0.75 ± 0.04
0.018
Kt/V (Gotch)
1.33 ± 0.17
1.29 ± 0.16
1.40 ± 0.16
1.41 ± 0.18
0.020
Female, n (%)
39 (48.8)
17 (33.3)
15 (78.9)
7 (70.0)
0.001
Diabetes mellitus, n (%)
33 (41.3)
25 (49.0)
6 (31.6)
2 (20.0)
0.145
Hypertension, n (%)
35 (43.8)
24 (47.1)
7 (36.8)
4 (40.0)
0.722
Values for continuous variables given as means ± standard deviation and test by one-way analysis of variance; variables not normally distributed given as medians and interquartile range and test by Kruskal–Wallis analysis. was considered statistically significant after the Kruskal–Wallis analysis or one-way analysis of variance.†Compared with the normal group and osteopenia group, ‡compared with normal group and osteoporosis group, and acompared with osteopenia group and osteoporosis group was and <0.05 considered statistically significant after Dunn's multiple comparison test or post hoc Bonferroni test. Kt/V, fractional clearance index for urea.
