Effects of Liraglutide on Left Ventricular Function: A Meta-Analysis of Randomized, Placebo-Controlled Trials

Table 2

Characteristics of included studies.

Study	Year	Liraglutide intervention	LG/CG	LVEF (%)	(cm/s)		Heart rate (bpm)
Kumarathurai et al. [18]	2021	0.6 mg/day, increased every 14 days up to 1.8 mg/day	LG	58.9 ± 7.2	5.7 ± 1.6	15.36 ± 6.4	68.6 ± 10.1
			CG
Paiman et al. [19]	2020	0.6 mg/day, increased every 7 days up to 1.8 mg/day	LG	56 ± 8	5.3 ± 2.1	7.4 ± 3.9	73 ± 13
			CG	57 ± 7	5.7 ± 1.9	7.4 ± 3.3	77 ± 11
Wagner et al. [20]	2019	0.6 mg/day, increased every 7 days up to 1.8 mg/day	LG	62 ± 7	NR	8.8 ± 2.3	NR
			CG	64 ± 5		9.7 ± 2.6
Bizino et al. [21]	2019	0.6 mg/day, increased every 7 days up to 1.8 mg/day	LG	55 ± 5.8	6.0 ± 1.6	7.3 ± 2.9	70 ± 9
			CG	55 ± 4.5	6.0 ± 1.8	7.9 ± 2.3	70 ± 12
Jorgensen et al. [22]	2017	0.6 mg/day, increased every 7 days up to 1.8 mg/day	LG	59.2 ± 6.1	NR	8.1 ± 1.9	80.4 ± 8.5
			CG	60.7 ± 6.6		8.2 ± 2.3	81.3 ± 8.3
Zhang et al. [23]	2017	0.6 mg/day for 2 days, 1.2 mg/day for 2 days, 1.8 mg/day for 3 days	LG	42.2 ± 7.1	NR	NR	67 ± 10
			CG	42.1 ± 7.3			67 ± 11
Jorsal et al. [24]	2017	0.6 mg/day, increased every 7 days up to 1.8 mg/day	LG	33.7 ± 7.6	6.6 ± 2.1	12.6 ± 6.0	76.3 ± 15.1 75.1 ± 9.6
			CG	35.4 ± 9.4	6.9 ± 2.4	11.7 ± 5.5
Chen et al. [25]	2016	0.6 mg/day for 2 days, 1.2 mg/day for 2 days, 1.8 mg/day for 3 days	LG	47.2 ± 5.1	NR	NR	71.7 ± 12.1
			CG	47.7 ± 5.1
Kumarathurai et al. [26]	2016	0.6 mg/day, increased every 14 days up to 1.8 mg/day	LG	58.9 ± 7.6	NR	NR	NR
			CG
Chen et al. [27]	2016	1.8 mg before intervention, 0.6 mg/day for 2 days, 1.2 mg/day for 2 days, 1.8 mg/day for 3 days	LG	51.3 ± 8.1	NR	NR	NR
			CG	50.7 ± 7.6

LG: liraglutide group; CG: control group; NR: not reported; LVEF: left ventricular ejection fraction; E: the value early diastolic filling velocity; : the mitral annular early diastolic velocity.