Angiopoietin-Like 8 in Gestational Diabetes Mellitus: Reduced Levels in Third Trimester Maternal Serum and Placenta, Increased Levels in Cord Blood Serum
Table 1
Characteristics of pregnant subjects with normal glucose tolerance (NGT) and pregnant subjects with diabetes mellitus (GDM).
Variable
NGT (n = 19)
GDM (n = 23)
Value
Age
28.00 (30.00–28.00)
30.00 (34.00–28.00)
0.195
Duration of pregnancy (day)
255.00 (268.00–225.00)
252.00 (252.00–217.00)
0.071
BMI (kg/m2)
26.72 ± 0.70
26.90 ± 0.84
0.872
FFA (ng/mL)
38.89 (75.59–22.67)
35.73 (60.35–22.44)
0.752
TC (mmol/L)
5.12 ± 0.25
5.66 ± 0.26
0.146
TG (mmol/L)
1.76 (2.25–1.46)
2.26 (2.96–1.85)
0.013
Insulin (uIU/mL)
7.00 ± 0.10
7.93 ± 0.15
<0.001
HOMA-IR
1.64 (1.92–1.17)
2.13 (2.34–1.93)
<0.001
OGTT-0h (mmol/L)
5.15 ± 0.14
6.08 ± 0.11
<0.001
OGTT-1h (mmol/L)
7.47 ± 0.17
11.40 ± 0.27
<0.001
OGTT-2h (mmol/L)
6.31 ± 0.17
8.68 ± 0.15
<0.001
Glucose AUC
13.21 ± 0.26
18.78 ± 0.27
<0.001
Birth weight (g)
3418.42 ± 97.94
3939.13 ± 116.85
0.002
Maternal serum ANGPTL8 (pg/mL)
1760.85 ± 139.13
1416.97 ± 89.97
0.046
Cord blood serum ANGPTL8 (pg/mL)
3077.81 ± 227.98
3883.1 ± 143.97
0.004
Statistically different from pregnant subjects with normal glucose tolerance ()
