Tumor Differentiation is the Dominant Prognostic Factor for Patients with Colorectal Neuroendocrine Neoplasms with Distant Metastasis

Table 4

Univariate and multivariate analysis of the risk factors of PFS and OS in the matched cohort.

Variables	PFS				OS
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Sex (male/female)	1.61 (0.72–3.60)	0.251			1.21 (0.48–3.05)	0.691
Age	0.99 (0.96–1.02)	0.525			1.00 (0.95–1.04)	0.831
BMI	1.04 (0.93–1.17)	0.477			1.10 (0.95–1.26)	0.202
Primary tumor location (colon/rectum)	1.26 (0.38–4.24)	0.707			0.52 (0.07–3.87)	0.519
Primary tumor size (>2 cm/≤ 2 cm)	1.17 (0.40–3.41)	0.774			1.77 (0.41–7.68)	0.449
Primary tumor shape (ulcerative/protruding)	1.12 (0.79–1.61)	0.525			2.80 (1.05–7.46)	0.039	2.10 (0.79–5.62)	0.139
Tumor differentiation (NEC/NET)	1.83 (0.84–3.99)	0.129			7.08 (2.28–22.01)	0.001	6.09 (1.96–18.95)	0.002
TNM T stage (T3 and T4/T1 and T2)	0.37 (0.05–3.00)	0.350			0.20 (0.02–1.68)	0.139
TNM N stage (N1/N0)	0.62 (0.22–1.81)	0.383			2.40 (0.32–18.12)	0.396
Extrahepatic metastasis (Yes/No)	0.69 (0.32–1.51)	0.354			0.76 (0.30–1.88)	0.548
Surgical resection (Yes/No)	1.13 (0.53–2.40)	0.761			1.71 (0.66–4.43)	0.268

PFS, progression-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; BMI, body mass index; NET, neuroendocrine tumor; NEC, neuroendocrine carcinoma.