Research Article

Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus

Table 1

Comparison of the clinical data between CVD group and non-CVD group.

VariableCVD (n = 95)Non-CVD (n = 155) value

Sex, M/F58/37105/500.281
Age, year66 (56–73)55 (45–66)<0.001
BMI, kg·m−224.40 (22.66–27.00)24.22 (22.10–26.45)0.187
WC, cm94 ± 1090 ± 100.004
HC, cm98 (94–104)97 (94–101)0.124
WHR0.94 (0.90–0.98)0.93 (0.89–0.96)0.054
Smokers30 (31.58%)51 (32.90%)0.828
Duration of diabetes, year10.0 (5.0–20.0)4.0 (0.3–10.0)<0.001
HbA1c, %9.6 (8.2–11.6)10.5 (8.8–12.1)0.022
FBG, mmol/L7.52 (6.19–9.60)7.47 (6.24–9.43)0.806
FCP, ng/mL1.28 (0.70–2.00)0.99 (0.54–1.70)0.074
2hCP, mIU/L3.33 (2.21–5.47)3.2 (2.19–4.84)0.383
HOMA-IR4.34 (2.37–6.53)3.79 (2.01–6.19)0.447
TG, mmol/L1.33 (1.09–2.14)1.47 (1.07–2.07)0.396
TC, mmol/L4.00 (3.48–5.17)4.82 (4.17–5.60)<0.001
LDL-C, mmol/L2.34 ± 0.962.97 ± 0.92<0.001
HDL-C, mmol/L0.93 (0.77–1.19)0.96 (0.84–1.13)0.342
UA, μmol/L334.8 (267.5–428.1)333.7 (271.8–403.8)0.805
eGFR, ml/min/1.73 m297 (83–109)109 (92–117)<0.001
DR28 (29.47%)31 (20.00%)0.087
DN17 (17.89%)8 (5.16%)0.001
Hypertension69 (72.63%)57 (36.77%)<0.001
TNC, pg/mL144.51 (122.99–182.47)127.24 (108.07–142.65)<0.001
Alarin, pg/mL126.59 (105.95–152.63)107.90 (98.37–126.21)<0.001

CVD, cardiovascular diseases; M/F, male/female; BMI, body mass index; WC, waist circumference; HC, hip circumference; WHR, waist-hip ratio; HbA1c, glycated hemoglobin; FBG, fasting blood glucose; FCP, fasting C-peptide; 2hCP, 2 h postprandial C-peptide; HOMA-IR, homeostasis model assessment of insulin resistance index; TG, triglycerides; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; UA, uric acid; eGFR, estimated glomerular filtration rate; DR, diabetic retinopathy; DN, diabetic nephropathy; TNC, tenascin-C.