Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells

Figure 2

Sestrin2 overexpression ameliorates TM-induced ER stress. (a) Representative western-blot results of Sestrin2 and ER stress-related proteins, ATF6, GRP78, CHOP, XBP1u and XBP1s in the indicated groups. (b) Western blot quantitative analysis of Sestrin2 (unpaired two-tailedt-test; t₍₄₎ = −38.44, ). (c) Western blot quantitative analysis of ER stress-related proteins (unpaired two-tailedt-test; for ATF6: t₍₄₎ = 4.32, P = 0.012; for GRP78: t₍₄₎ = 4.54, ). , .

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