Combination Therapy with GABA and MgSO₄ Improves Insulin Sensitivity in Type 2 Diabetic Rat

Figure 2

Comparison of insulin tolerance test (a) and the area under the glycemic curve (AUC) (b) and GIR (c) 3 months after treatment in the nondiabetic control group (NDC) who received a normal diet, the group with chronic diabetic fed high-fat diet and 35 mg/Kg STZ (d), diabetic animals treated with insulin (2.5  U/Kg two times per day) (Ins-D), and animals with diabetes receiving GABA treatment GABA (1.5gr/kg) + MgSO₄ (10 g/l add in drinking water) (GABA + Mg-D) (10 rats in each group. Data are expressed as mean ± SEM). (a) Significant difference between D and other groups ( < 0.0001). (b) Significant difference between GABA + Mg-D and Ins-D group ( < 0.001). (c) Significant difference between NDC group and GABA + Mg-D ( < 0.01).

(a)

(b)

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