Combination Therapy with GABA and MgSO₄ Improves Insulin Sensitivity in Type 2 Diabetic Rat

Figure 4

Comparison of food intake (a), urine volume (b), and water consumption. (c) In the nondiabetic control group (NDC) fed with a normal diet, the chronic diabetic group received high-fat diet and 35 mg/Kg STZ (D), diabetic animals treated with insulin (2.5 U/Kg two times per day) (Ins-D), and diabetic animals treated with GABA (1.5gr/kg) + MgSO₄ (10 g/l add in drinking water) (GABA + Mg-D) (10 rats in each group; data are expressed as mean ± SEM). (a) Significant difference between D and other groups ( < 0.001). (b) Significant difference between GABA + Mg-D and Ins-D group ( < 0.01). (c) Significant difference between NDC group and GABA + Mg-D ( < 0.01).

(a)

(b)

(c)