Combination Therapy with GABA and MgSO₄ Improves Insulin Sensitivity in Type 2 Diabetic Rat

Figure 6

Comparison of immunohistochemistry for GLUT4 in the nondiabetic control group (NDC) fed with a normal diet, the chronic diabetic group received high-fat diet and 35 mg/Kg STZ (D), diabetic animals treated with insulin (2.5 U/Kg two times per day) (Ins-D), and diabetic animals treated with GABA (1.5gr/kg) + MgSO₄ (10 g/l add in drinking water) (GABA + Mg-D) (10 rats in each group. Data are expressed as mean ± SEM) (X400, black arrows indicate the translocation of GLUT4 to the cell membrane).