Bidirectional Mendelian Randomization Analysis for Vitamin D and Thyroid Peroxidase Antibody

Table 1

Information of each SNP in GRS.

Gene	Chromosome	Position	SNP	Effect allele	EAF	X^2	P For HWE
Vitamin D-related SNPs
GC	4	71742666	rs2282679	G	0.32	0.02	>0.05
CYP2R1	11	14893332	rs10741657	G	0.64	1.58	>0.05
DHCR7	11	71456403	rs12785878	G	0.55	1.04	>0.05
CYP24A1	20	54125940	rs6013897	A	0.16	7.61	0.005<
TPOAb-related SNPs
HLA-DPB1	6	33087828	rs9277555	G	0.49	4.60	0.01<
TPO	2	1404043	rs11675434	T	0.31	0.94	>0.05
RERE	1	8429242	rs301799	C	0.17	0.28	>0.05
HCP5	6	31462150	rs3094228	G	0.15	7.31	0.005<

EAF, Effect allele frequency; GRS, gDQenetic risk score; HWE, Hardy-Weinberg equilibrium; SNP, Single nucleotide polymorphism.