Bidirectional Mendelian Randomization Analysis for Vitamin D and Thyroid Peroxidase Antibody
Table 2
Association of each individual SNP with confounders.
SNP
Age
Waist to hip ratio
BMI
Sex
B (SE)
B (SE)
B (SE)
OR (95% CI)
Vitamin D-related SNPs
rs2282679
0.185 (0.180)
0.306
0.000 (0.001)
0.916
0.023 (0.049)
0.638
0.983 (0.922, 1.049)
−0.017
rs10741657
−0.011 (0.177)
0.951
0.000 (0.001)
0.858
−0.017 (0.048)
0.728
1.023 (0.960, 1.089)
0.485
rs12785878
0.210 (0.171)
0.219
0.000 (0.001)
0.835
0.025 (0.046)
0.585
0.957 (0.901, 1.018)
0.162
rs6013897
0.185 (0.226)
0.412
−0.001 (0.001)
0.331
−0.037 (0.061)
0.548
0.935 (0.863, 1.013)
0.099
Vitamin D-related SNPs
rs9277555
0.165 (0.171)
0.334
−0.001 (0.001)
0.322
0.030 (0.046)
0.521
1.007 (0.948, 1.070)
0.819
rs11675434
−0.120 (0.183)
0.512
0.002 (0.001)
0.083
0.031 (0.050)
0.529
1.014 (0.950, 1.083)
0.676
rs301799
−0.144 (0.224)
0.521
0.001 (0.001)
0.528
−0.007 (0.061)
0.909
1.033 (0.953, 1.119)
0.432
rs3094228
0.415 (0.236)
0.079
−0.001 (0.001)
0.684
0.054 (0.064)
0.398
1.046 (0.961, 1.138)
0.295
Data are expressed as unstandardized coefficients (standard error) and odds ratio (95% confidence interval). Multiple linear and logistic regression was performed. The model was adjusted for age (not for age), sex (not for sex), and waist to hip ratio (not for BMI and waist to hip ratio).
