Bidirectional Mendelian Randomization Analysis for Vitamin D and Thyroid Peroxidase Antibody

Table 3

Association of the GRSs with confounders.

	VD_GRS		TPOAb_GRS
Continuous variable	B (SE)		B (SE)
Age	0.498 (0.346)	0.150	0.827 (1.123)	0.462
BMI	−0.016 (0.101)	0.871	0.422 (0.328)	0.199
Waist to hip ratio	0.000 (0.002)	0.808	0.003 (0.007)	0.625
Ln 25 (OH) D	−0.093 (0.009)	<0.001	−0.030 (0.031)	0.330
lnTPOAb	0.067 (0.033)	0.043	0.345 (0.107)	0.001
Categorical variable	OR (95%CI)		OR (95%CI)
Sex	0.931 (0.823, 1.054)	0.259	1.231 (0.823, 1.840)	0.311

Data are expressed as unstandardized coefficients (standard error) and odds ratio (95% confidence interval). Multiple linear and logistic regression was performed. The model was adjusted for age (not for age), sex (not for sex) and waist to hip ratio (not for BMI and waist to hip ratio).