Bidirectional Mendelian Randomization Analysis for Vitamin D and Thyroid Peroxidase Antibody
Table 4
Characteristics of study participants according to the weighted vitamin D genetic risk score (VD_GRS) and weighted TPOAb_GRS (n = 10636).
Characteristics
VD_GRS
Q1
Q2
Q3
For trend
VD_GRS
≤0.82
0.83 – 1.13
≥1.14
N
3477
3623
3536
Age, years
54.64 ± 13.02
54.76 ± 12.98
55.15 ± 12.69
0.219
Male (%)
39.2
40.7
40.0
0.439
Smokers (%)
19.1
20.9
20.6
0.146
BMI (kg/m2)
24.62 ± 3.49
24.63 ± 3.67
24.65 ± 3.59
0.941
Waist to hip ratio
0.86 ± 0.08
0.86 ± 0.08
0.86 ± 0.08
0.574
SBP (mmHg)
132.35 ± 21.24
132.55 ± 21.72
132.76 ± 21.69
0.738
25 (OH) D (mmol/L)
41.89 ± 13.22
40.80 ± 12.72
39.02 ± 11.96
<0.001
TPOAb (U/ml)
108.45 ± 289.42
113.84 ± 297.72
121.46 ± 310.48
0.019
TPOAb_GRS
Q1
Q2
Q3
For trend
TPOAb_GRS
≤0.136
0.137 – 0.240
≥0.241
N
3660
3842
3134
Age, years
54.72 ± 13.28
54.92 ± 12.68
54.92 ± 12.71
0.750
Male (%)
40.9
40.0
38.9
0.252
Smokers (%)
20.7
20.1
19.9
0.719
BMI (kg/m2)
24.54 ± 3.56
24.71 ± 3.60
24.64 ± 3.61
0.126
Waist to hip ratio
0.86 ± 0.08
0.86 ± 0.08
0.86 ± 0.08
0.242
SBP (mmHg)
132.67 ± 21.62
132.20 ± 21.41
132.87 ± 21.64
0.415
25 (OH) D (mmol/L)
40.59 ± 12.57
40.68 ± 12.81
40.40 ± 12.93
0.435
TPOAb (U/ml)
104.67 ± 283.87
119.49 ± 307.07
120.24 ± 307.21
0.021
The data are summarized as the mean ± SD for continuous variables or as a numerical proportion for categorical variables. P for trend was calculated by ANOVA and chi-square tests. 25 (OH) D, 25-hydroxyvitamin D; GRS, genetic risk score.
