Bidirectional Mendelian Randomization Analysis for Vitamin D and Thyroid Peroxidase Antibody

Table 5

Associations of VD_GRS and 25 (OH) D with TPOAb concentration.

	Model 1	Model 2
VD_GRS	0.066 (0.002, 0.129)	0.067 (0.002, 0.132)
Tertiles of VD_GRS
Q1	0.000 (ref)	0.000 (ref)
Q2	0.009 (−0.045, 0.062)	0.007 (−0.047, 0.062)
Q3	0.061 (0.007, 0.114)	0.060 (0.006, 0.115)
For trend	0.027	0.031
25 (OH) D	0.069 (0.003, 0.135)	0.070 (0.003, 0.137)

Data were presented as and 95% confidence interval. 25 (OH) D, 25-hydroxyvitamin D; GRS, genetic risk score; Model 1 adjusted for age and sex; Model 2 adjusted for terms in model 1 and waist to hip ratio.