sCD40L Is Increased and Associated with the Risk of Gestational Diabetes Mellitus in Pregnant Women with Isolated TPOAb Positivity

Table 1

Baseline and demographical characteristics and laboratory parameters of TPOAb-positive pregnancies and TPOAb-negative controls.

	TPOAb-positive	TPOAb-negative	Value
Age (y)	30.19 ± 3.99	29 ± 2.94	0.118
Gestational weeks	13.18 ± 2.16	12.98 ± 1.66	0.633
Prepregnancy BMI (kg/m^2)	22.15 ± 2.88	21.80 ± 2.70	0.543
Gravida	2 (1–6)	2 (1–4)	0.124
Parity	0 (0–2)	0 (0–1)	0.812
Medically assisted reproduction	6 (6.45%)	4 (12.12%)	0.301
TSH (µIU/L)	1.83 ± 0.71	1.24 ± 0.87	<0.001
FT4 (pmol/L)	12.76 ± 1.31	13.59 ± 2.41	0.067
HbA1c (%)	5.18 ± 0.29	5.16 ± 0.30	0.829
FPG (mmol/L)	4.59 ± 0.39	4.68 ± 0.36	0.244
UA (mmol/L)	209.46 ± 51.95	224.68 ± 42.80	0.134
TG (mmol/L)	1.59 ± 0.72	1.32 ± 0.37	<0.05
TC (mmol/L)	4.92 ± 0.81	4.82 ± 0.84	0.513
HDL-c (mmol/L)	1.83 ± 0.36	1.84 ± 0.33	0.923
LDL-c (mmol/L)	2.56 ± 0.68	2.54 ± 0.75	0.881
CRP (mmol/L)	2.76 (1.33–4.63)	1.35 (0.97–3.78)	0.091
WBC (×10^9/L)	8.61 ± 1.86	8.57 ± 1.34	0.906
RBC (×10^12/L)	4.21 ± 0.41	4.16 ± 0.27	0.540
Hb (g/L)	127.27 ± 9.79	127.30 ± 9.14	0.986
Plt (×10^9/L)	229.72 ± 54.17	231.91 ± 55.07	0.843
GDM (N, %)	22, 24.4%	6, 18.18%	0.628
sCD40L(ng/mL)	4.93 ± 0.62	3.83 ± 1.29	<0.001
sCD25(ng/mL	0.70 ± 0.24	0.57 ± 0.21	<0.05

is statistically significant. BMI, body mass index; TPOAb, thyroid peroxidase antibody; TSH, thyroid-stimulating hormone; FT4, free thyroxine; HbA1c, glycosylated hemoglobin A1c; FPG, fasting plasma glucose; UA, uric acid; TG, triglyceride; TC, total cholesterol; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; CRP, C-reactive protein; WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; Plt, platelet; GDM, gestational diabetes mellitus; sCD40L, soluble CD40 ligand; sCD25, soluble CD25.