sCD40L Is Increased and Associated with the Risk of Gestational Diabetes Mellitus in Pregnant Women with Isolated TPOAb Positivity

Table 2

The comparison of baseline and laboratory parameters of participants with or without GDM in early pregnancy.

Variables	TPOAb-positive		TPOAb-negative		Value
	Non-GDM	GDM	Non-GDM	GDM
Age (y)	29.69 ± 3.69	32.14 ± 4.4^ac	29.3 ± 2.89	27.67 ± 3.01	<0.05
Gestational weeks	13.17 ± 2.27	13.30 ± 1.95	12.91 ± 1.72	13.31 ± 1.45	0.916
Prepregnancy BMI(kg/m2)	21.81 ± 2.70	23.49 ± 3.05	21.98 ± 2.64	20.97 ± 3.07	0.068
Gravida	2 (1–3)	2 (1–3)	2 (1–2)	2 (1–3)	0.544
Parity	0 (0-1)	0 (0–1)	0 (0–1)	0 (0–1)	0.783
TSH(µIU/mL)	1.90 ± 0.71^ab	1.64 ± 0.73	1.32 ± 0.92	0.90 ± 0.55	0.001
FT4(pmol/L)	12.76 ± 1.27	12.60 ± 1.38	13.76 ± 2.53	12.85 ± 1.82	<0.05
UA(µmol/L)	207.73 ± 54.41	215.64 ± 47.56	226.00 ± 42.63	218.75 ± 47.17	0.454
TG(mmol/L)	1.51 ± 0.68	1.92 ± 0.79^a	1.33 ± 0.35	1.25 ± 0.47	<0.05
TC(mmol/L)	4.83 ± 0.79	5.26 ± 0.82	4.90 ± 0.87	4.42 ± 0.60	0.082
HDL-c(mmol/L)	1.81 ± 0.36	1.91 ± 0.37	1.82 ± 0.35	1.95 ± 0.23	0.588
LDL-c(mmol/L)	2.49 ± 0.65	2.82 ± 0.72	2.66 ± 0.75	2.01 ± 0.53	<0.05
CRP(mg/L)	2.46 (1.15–3.95)	3.85 (2.00–6.64)	1.35 (1.04–3.95)	1.74 (0.68–3.38)	0.134
WBC(x10^9/L)	8.43 ± 1.85	9.24 ± 1.90	8.49 ± 1.28	8.96 ± 1.66	0.269
RBC(x10^12/L)	4.18 ± 0.42	4.33 ± 0.37	4.16 ± 0.26	4.17 ± 0.33	0.365
Hb(g/L)	126.65 ± 10.01	130.05 ± 9.17	128.33 ± 8.70	122.67 ± 10.44	0.290
Plt(x10^9/L)	228.76 ± 54.74	232.55 ± 56.28	232.81 ± 56.99	227.83 ± 49.95	0.984
sCD40L(ng/mL)	4.84 ± 0.63^a	5.15 ± 0.49^a	3.72 ± 1.27	4.32 ± 1.37	<0.001
sCD25(ng/mL)	0.69 ± 0.24	0.70 ± 0.20	0.56 ± 0.15	0.61 ± 0.40	0.073

Adjustment for multiple comparisons: Bonferroni correction.(a) compared with negative-TPOAb women without GDM, .(b) compared with negative-TPOAb women with GDM, .(c) compared with positive-TPOAb women without GDM, . BMI, body mass index; TPOAb, thyroid peroxidase antibody; TSH, thyroid-stimulating hormone; FT4, free thyroxine; UA, uric acid; TG, triglyceride; TC, total cholesterol; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; sCD40L, soluble CD40 ligand; sCD25, soluble CD25.