Central Obesity Is Associated with Variations in TSH and ACTH Levels among Euthyroid Obese Individuals

Table 1

The distribution of demographic data and metabolic indicators across the TSH quartiles in overweight or obese individuals.

TSH quartiles (μIU/ml)		≤1.55	1.56–2.24	2.25–3.14	≥3.15	value
Age (year)	N	112	108	109	110	0.621
	Mean ± SD	35.1 ± 12.3	36.9 ± 14.2	34.7 ± 12.1	35.6 ± 12.3
Sex (male/female)	N	36/76	40/72	24/83	23/87	0.034
Dyslipidemia	N, %	50, 44.6%	50, 44.6%	42, 39.3%	53, 48.2%	0.618
DM	N, %	35, 31.3%	32, 28.6%	31, 29.0%	35, 31.8%	0.938
HT	N, %	29, 25.9%	36, 32.1%	23, 21.5%	36, 32.7%	0.199
NAFLD	N, %	83, 74.1%	94, 83.9%	79, 73.8%	82, 74.5%	0.215
Gout	N, %	3, 2.7%	8, 7.1%	5, 4.7%	2, 1.8%	0.189
Hyperuricemia	N, %	34, 30.4%	31, 27.7%	29, 27.1%	27, 24.5%	0.813
PCOS	N, %	12, 15.8%	11, 15.3%	18, 21.7%	14, 16.1%	0.675
FT3 (pmol/L)	N	54	54	48	63	0.521
	Mean ± SD	4.68 ± 0.93	4.58 ± 0.67	4.77 ± 0.89	4.78 ± 0.59
FT4 (pmol/L)	N	53	51	45	64	0.183
	Mean ± SD	15.92 ± 2.68	15.20 ± 2.00	15.03 ± 2.10	15.11 ± 2.38
TT3 (nmol/L)	N	104	99	95	99	0.408
	Mean ± SD	1.73 ± 0.37	1.74 ± 0.29	1.77 ± 0.30	1.80 ± 0.31
TT4 (nmol/L)	N	103	99	95	99	0.473
	Mean ± SD	104.6 ± 20.6	101.2 ± 19.8	102.1 ± 19.5	105.1 ± 21.7
Weight (kg)	N	112	108	110	110	0.436
	Mean ± SD	98.3 ± 8.9	92.4 ± 1.9	90.8 ± 1.8	104.8 ± 9.5
BMI (kg/m^2)	N	112	108	110	110	0.002
	Mean ± SD	32.4 ± 4.6	33.5 ± 5.7	32.8 ± 4.5	34.9 ± 6.1
WC (cm)	N	111	107	110	109	0.090
	Mean ± SD	101.0 ± 13.0	102.1 ± 14.5	101.7 ± 12.5	105.3 ± 13.9
HC (cm)	N	111	107	110	109	0.021
	Mean ± SD	110.9 ± 9.2	112.4 ± 12.2	111.5 ± 9.4	115.2 ± 12.8
BF (%)	N	111	108	110	110	0.151
	Mean ± SD	41.5 ± 11.6	41.7 ± 6.4	41.5 ± 5.7	44.1 ± 13.1
Muscle mass of upper extremities (kg)	N	92	98	95	97	0.722
	Mean ± SD	5.74 ± 1.65	5.81 ± 1.53	5.71 ± 1.47	5.95 ± 1.63
Muscle mass of lower extremities (kg)	N	92	98	95	97	0.636
	Mean ± SD	16.17 ± 3.94	16.21 ± 3.31	16.11 ± 3.56	16.72 ± 3.71
Muscle mass (kg)	N	93	99	95	97	0.751
	Mean ± SD	29.07 ± 7.34	29.05 ± 6.50	28.64 ± 6.27	29.71 ± 7.01
BMR (kCal)	N	109	105	108	107	0.766
	Mean ± SD	1548.6 ± 307.0	1539.0 ± 297.5	1539.7 ± 274.5	1576.4 ± 290.8
Daily calorie intake (kCal)	N	38	29	31	33	0.626
	Mean ± SD	2256.3 ± 158.3	2199.3 ± 144.0	2147.5 ± 113.6	2018.9 ± 109.2
Fasting insulin (μIU/ml)	N	68	83	86	73	0.027
	Mean ± SD	23.81 ± 1.92	24.73 ± 2.15	24.17 ± 1.62	32.88 ± 3.65
Fasting C-peptide (ng/ml)	N	65	78	77	64	0.053
	Mean ± SD	3.70 ± 1.45	3.47 ± 1.56	3.79 ± 1.74	4.23 ± 1.82
Cortisol (μg/dl)	N	76	81	86	76	0.485
	Mean ± SD	13.94 ± 5.62	14.34 ± 5.80	13.80 ± 4.98	15.03 ± 5.15
ACTH (pg/ml)	N	75	81	82	78	<0.001
	Mean ± SD	26.55 ± 16.83	27.03 ± 13.53	26.57 ± 13.16	36.74 ± 23.10
HbA1c (%)	N	58	58	70	57	0.780
	Mean ± SD	6.60 ± 1.49	6.61 ± 1.74	6.36 ± 1.38	6.51 ± 1.50
ALT (IU/L)	N	85	85	85	77	0.806
	Mean ± SD	45.36 ± 4.28	44.51 ± 3.72	48.28 ± 5.93	50.59 ± 5.04
AST (IU/L)	N	84	82	86	76	0.422
	Mean ± SD	28.98 ± 2.24	27.12 ± 1.68	31.12 ± 2.87	32.59 ± 2.81
UA (μmol/L)	N	83	83	84	77	0.532
	Mean ± SD	397.9 ± 115.2	387.9 ± 112.8	372.3 ± 122.0	381.3 ± 108.4
TG (mmol/L)	N	84	86	85	75	0.287
	Mean ± SD	2.18 ± 1.69	1.91 ± 1.34	1.82 ± 0.97	2.11 ± 1.38
TCHO (mmol/L)	N	83	84	84	74	0.332
	Mean ± SD	4.87 ± 0.99	4.73 ± 1.08	4.75 ± 0.93	5.02 ± 1.40
HDL (mmol/L)	N	84	86	83	75	0.938
	Mean ± SD	1.13 ± 0.23	1.11 ± 0.22	1.11 ± 0.37	1.11 ± 0.22
LDL (mmol/L)	N	84	86	83	74	0.245
	Mean ± SD	3.01 ± 0.73	3.01 ± 0.80	2.96 ± 0.80	3.22 ± 1.05

DM, diabetes mellitus; HT, hypertension; NAFLD, nonalcoholic fatty liver disease; PCOS, polycystic ovary syndrome; BMR, basal metabolic rate; BMI, body mass index; WC, waist circumference; HC, hip circumference; BF, body fat percentage; ACTH, adrenocorticotropic hormone; ALT, alanine aminotransferase; AST, glutamic oxaloacetic transaminase; UA, uric acid; TG, triglyceride; TCHO, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein.