Central Obesity Is Associated with Variations in TSH and ACTH Levels among Euthyroid Obese Individuals

Table 2

The distribution of demographic data and metabolic indicators across the TSH quartiles in the female subgroup.

TSH quartiles (μIU/ml)		≤1.55	1.56–2.24	2.25–3.14	≥3.15	value
Age (year)	N	76	72	83	86	0.808
	Mean ± SD	36.5 ± 12.9	38.1 ± 14.4	36.3 ± 12.2	37.3 ± 12.6
FT3 (pmol/L)	N	42	38	38	52	0.599
	Mean ± SD	4.54 ± 0.93	4.54 ± 0.66	4.72 ± 0.87	4.66 ± 0.50
FT4 (pmol/L)	N	41	36	36	53	0.166
	Mean ± SD	15.69 ± 2.66	15.31 ± 2.09	14.93 ± 2.13	14.70 ± 2.03
TT3 (nmol/L)	N	69	66	68	76	0.720
	Mean ± SD	1.72 ± 0.41	1.73 ± 0.28	1.75 ± 0.32	1.78 ± 0.32
TT4 (nmol/L)	N	68	66	68	99	0.460
	Mean ± SD	107.3 ± 20.1	102.9 ± 19.8	102.4 ± 18.8	105.2 ± 21.4
Weight (kg)	N	76	72	83	86	0.150
	Mean ± SD	82.4 ± 11.9	85.9 ± 17.2	84.9 ± 13.9	101.6 ± 12.1
BMI (kg/m^2)	N	76	72	83	86	0.010
	Mean ± SD	31.5 ± 4.1	32.9 ± 5.9	32.0 ± 4.2	34.1 ± 6.3
WC (cm)	N	76	71	83	85	0.007
	Mean ± SD	96.1 ± 10.9	97.4 ± 11.9	98.0 ± 10.4	102.1 ± 13.2
HC (cm)	N	76	71	83	85	0.082
	Mean ± SD	109.4 ± 8.8	111.5 ± 11.9	110.2 ± 9.0	113.5 ± 12.9
BF (%)	N	76	72	83	86	0.119
	Mean ± SD	42.2 ± 5.3	44.4 ± 5.4	42.8 ± 5.2	45.2 ± 14.3
Muscle mass of upper extremities (kg)	N	65	65	73	75	0.056
	Mean ± SD	4.91 ± 0.79	4.98 ± 0.98	5.09 ± 0.92	5.30 ± 0.92
Muscle mass of lower extremities (kg)	N	65	65	73	75	0.020
	Mean ± SD	14.23 ± 1.88	14.42 ± 2.11	14.63 ± 2.21	15.30 ± 2.33
Muscle mass (kg)	N	66	66	73	75	0.109
	Mean ± SD	25.56 ± 4.01	25.45 ± 3.98	25.97 ± 3.85	26.91 ± 3.94
BMR (kCal)	N	76	70	82	84	0.050
	Mean ± SD	1417.4 ± 214.2	1400.3 ± 186.3	1431.8 ± 181.4	1484.6 ± 214.7
Fasting insulin (μIU/ml)	N	42	56	64	55	0.080
	Mean ± SD	24.46 ± 2.72	23.29 ± 2.57	22.62 ± 1.59	32.38 ± 4.64
Fasting C-peptide (ng/ml)	N	39	53	54	48	0.031
	Mean ± SD	3.44 ± 1.45	3.35 ± 1.64	3.45 ± 1.26	4.20 ± 1.94
Cortisol (μg/dl)	N	48	54	63	59	0.168
	Mean ± SD	12.89 ± 4.57	13.53 ± 3.95	14.07 ± 4.71	14.84 ± 5.16
ACTH (pg/ml)	N	47	55	60	60	0.002
	Mean ± SD	22.94 ± 11.83	24.94 ± 12.64	25.45 ± 11.81	33.32 ± 21.75
HbA1c (%)	N	38	36	54	44	0.995
	Mean ± SD	6.39 ± 1.38	6.34 ± 1.18	6.36 ± 1.45	6.41 ± 1.31
UA (μmol/L)	N	54	56	61	58	0.708
	Mean ± SD	364.6 ± 12.4	359.5 ± 14.2	347.5 ± 12.6	365.9 ± 10.8
Progesterone (ng/ml)	N	25	33	39	33	0.809
	Mean ± SD	1.87 ± 0.78	2.54 ± 0.89	3.07 ± 0.83	2.58 ± 0.78
Testosterone (ng/ml)	N	24	33	40	34	0.227
	Mean ± SD	1.31 ± 0.42	0.67 ± 0.06	0.73 ± 0.08	1.81 ± 0.82
Estradiol (pg/ml)	N	26	34	39	34	0.625
	Mean ± SD	82.85 ± 15.08	80.19 ± 10.91	103.79 ± 19.29	80.32 ± 14.33
FSH (mIU/ml)	N	26	34	40	36	0.087
	Mean ± SD	6.16 ± 0.68	12.75 ± 3.03	7.59 ± 1.46	7.39 ± 1.41
LH (mIU/ml)	N	26	36	40	36	0.192
	Mean ± SD	12.63 ± 3.59	9.32 ± 1.21	9.09 ± 1.26	6.94 ± 0.88

BMR, basal metabolic rate; BMI, body mass index; WC, waist circumference; HC, hip circumference; BF, body fat percentage; ACTH, adrenocorticotropic hormone; UA, uric acid; FSH, follicle-stimulating hormone; LH, luteinizing hormone.