Central Obesity Is Associated with Variations in TSH and ACTH Levels among Euthyroid Obese Individuals

Table 4

The distribution of demographic data and metabolic indicators across the ACTH quartiles in overweight or obese individuals.

ACTH quartiles (pg/ml)		≤17.31	17.36–25.24	25.26–37.02	>37.05	value
Age (year)	N	80	79	79	79	0.466
	Mean ± SD	35.1 ± 11.6	32.1 ± 12.6	34.0 ± 11.2	33.5 ± 12.9
Sex (male/female)	N	15/65	25/54	19/60	35/44	0.003
TSH (μIU/ml)	N	79	79	79	79	0.206
	Mean ± SD	2.41 ± 1.56	2.62 ± 2.24	2.73 ± 1.42	3.04 ± 2.18
FT3 (pmol/L)	N	29	33	33	39	0.005
	Mean ± SD	4.56 ± 0.86	4.53 ± 0.76	4.98 ± 0.49	5.02 ± 0.69
FT4 (pmol/L)	N	27	30	35	38	0.456
	Mean ± SD	14.89 ± 2.58	15.44 ± 2.50	15.76 ± 1.87	15.24 ± 1.83
TT3 (nmol/L)	N	71	70	75	76	0.277
	Mean ± SD	1.73 ± 0.31	1.80 ± 0.37	1.80 ± 0.32	1.83 ± 0.28
TT4 (nmol/L)	N	71	70	75	76	0.479
	Mean ± SD	101.8 ± 20.0	104.6 ± 21.6	104.6 ± 21.0	100.2 ± 19.0
Weight (kg)	N	80	79	79	79	<0.001
	Mean ± SD	88.3 ± 16.3	94.1 ± 18.1	89.3 ± 17.5	101.6 ± 21.1
BMI (kg/m^2)	N	80	79	79	79	<0.001
	Mean ± SD	32.6 ± 4.2	33.8 ± 5.7	32.6 ± 5.1	35.8 ± 5.4
WC (cm)	N	80	79	79	79	<0.001
	Mean ± SD	100.2 ± 11.5	103.6 ± 13.0	99.3 ± 13.3	109.7 ± 13.9
HC (cm)	N	80	79	79	79	<0.001
	Mean ± SD	110.2 ± 9.1	114.2 ± 12.6	110.6 ± 9.2	117.0 ± 11.8
BF (%)	N	80	78	79	79	0.553
	Mean ± SD	42.4 ± 5.7	43.4 ± 5.5	41.3 ± 5.7	42.1 ± 6.7
Muscle mass of upper extremities (kg)	N	71	65	72	64	0.003
	Mean ± SD	5.52 ± 1.49	5.92 ± 1.44	5.69 ± 1.49	6.46 ± 1.70
Muscle mass of lower extremities (kg)	N	71	65	72	64	0.006
	Mean ± SD	15.71 ± 3.38	16.72 ± 3.30	16.12 ± 3.51	17.77 ± 4.02
Muscle mass (kg)	N	72	66	72	64	0.005
	Mean ± SD	27.81 ± 6.38	29.72 ± 6.19	28.72 ± 6.39	31.77 ± 7.43
Fasting insulin (μIU/ml)	N	64	72	72	71	0.037
	Mean ± SD	26.81 ± 2.68	26.04 ± 2.27	22.04 ± 1.71	32.47 ± 3.38
Fasting C-peptide (ng/ml)	N	57	68	69	66	0.077
	Mean ± SD	3.70 ± 1.81	3.89 ± 1.79	3.48 ± 1.31	4.20 ± 1.68
Cortisol (μg/dl)	N	80	78	78	75	<0.001
	Mean ± SD	11.61 ± 4.95	12.62 ± 3.68	15.13 ± 4.77	17.40 ± 5.53
HbA1c (%)	N	44	49	52	53	0.410
	Mean ± SD	6.30 ± 1.13	6.60 ± 1.67	6.82 ± 2.02	6.45 ± 1.33
ALT (IU/L)	N	63	67	64	67	0.582
	Mean ± SD	39.95 ± 4.64	49.68 ± 7.45	49.20 ± 5.31	47.92 ± 4.17
AST (IU/L)	N	62	67	63	66	0.556
	Mean ± SD	26.28 ± 2.25	28.92 ± 2.88	31.33 ± 3.25	31.16 ± 2.71
TG (mmol/L)	N	64	68	66	65	0.145
	Mean ± SD	1.76 ± 1.22	1.89 ± 1.31	2.19 ± 1.47	2.26 ± 1.70
TCHO (mmol/L)	N	63	67	65	64	0.375
	Mean ± SD	4.73 ± 0.84	4.65 ± 1.03	4.94 ± 0.98	4.91 ± 1.50
HDL (mmol/L)	N	63	68	66	65	0.521
	Mean ± SD	1.09 ± 0.23	1.13 ± 0.23	1.12 ± 0.38	1.07 ± 0.21
LDL (mmol/L)	N	63	68	66	64	0.315
	Mean ± SD	2.93 ± 0.75	2.91 ± 0.73	3.15 ± 0.76	3.05 ± 1.11

BMI, body mass index; WC, waist circumference; HC, hip circumference; BF, body fat percentage; ACTH, adrenocorticotropic hormone; TSH, thyroid-stimulating hormone; ALT, alanine aminotransferase; AST, glutamic oxaloacetic transaminase; UA, uric acid; TG, triglyceride; TCHO, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein.