Fufang Xueshuantong Improves Diabetic Cardiomyopathy by Regulating the Wnt/β-Catenin Pathway

Figure 4

FXST alleviated STZ-induced cardiac fibrosis in DM rats. (a) Representative images of Masson staining of myocardial tissues (400×, magnification). Arrows represent the fibrotic area. (b) The quantification analysis of the collagen volume fraction of myocardial tissues. Representative immunofluorescence images were shown for the expression of collagen I (c), collagen III (e), and TGF-β1 (g). The expression level of collagen I (d), collagen III (f), and TGF-β1 (h) was detected and quantified. (i–k) Western blot was used to determine the protein expression of collagen I, collagen III, and TGF-β1 in the myocardial tissues of rats in each group. Data are expressed as the mean ± SD (n = 3–5 for each group). Scale bar = 50 μm. , , vs. the Control group, ^#, ^##, ^### vs. the DM group.

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