The Predictive Levels of Serum Anti-Müllerian Hormone and the Combined Index of the Number of Retrieved Oocytes and Good-Quality Embryos in Advanced-Age Infertile Women

Table 1

Clinical data and variables’ data of different age groups.

Variables	Age groups				value
	Total subjects (n = 521), mean ± SD	Group 1 (21–34 years) (n = 64), mean ± SD	Group 2 (35–39 years) (n = 296), mean ± SD	Group 3 (40–46 years) (n = 161), mean ± SD
Female age (years)	37.72 ± 4.25	29.11 ± 3.25	37.23 ± 1.15	42.06 ± 1.79	0.001
Duration of infertility (years)^#	4.99 ± 3.94	3.92 ± 2.34	4.86 ± 3.70	5.74 ± 4.77	0.008
BMI (kg/m^2)	23.41 ± 4.16	22.80 ± 3.10	23.33 ± 4.14	23.82 ± 4.57	0.254
AFC^#	12.65 ± 6.99	19.02 ± 7.34	12.79 ± 7.00	9.92 ± 4.94	0.001
AMH (ng/ml)^#	3.295 ± 2.55	3.59 ± 2.30	3.56 ± 2.82	2.68 ± 1.98	0.001
AFC/age ratio^#	0.350 ± 0.221	0.660 ± 0.262	0.345 ± 0.192	0.239 ± 0.122	0.001
AMH/age ratio^#	0.090 ± 0.072	0.126 ± 0.085	0.096 ± 0.076	0.064 ± 0.047	0.001
ORPI^#	1.31 ± 1.51	2.58 ± 2.06	1.38 ± 1.52	0.68 ± 0.67	0.001
FSH (IU/liter)	7.08 ± 3.90	6.64 ± 3.88	7.12 ± 4.25	7.20 ± 3.16	0.636
LH (IU/liter)	4.52 ± 5.06	4.12 ± 2.92	5.02 ± 6.30	3.81 ± 2.64	0.051
FSH/LH ratio	2.28 ± 3.43	2.54 ± 2.74	2.19 ± 4.25	2.31 ± 1.30	0.781
E2 (pg/ml)	122.75 ± 349.98	90.17 ± 112.27	105.63 ± 287.77	168.49 ± 491.27	0.165
TT (nmol/liter)	1.06 ± 6.74	0.43 ± 0.19	1.55 ± 8.88	0.40 ± 0.19	0.453
NOR^#	11.72 ± 6.77	12.03 ± 7.05	12.44 ± 7.25	10.27 ± 5.40	0.004
Fertilization rate (%)	76.18 ± 28.75	71.34 ± 21.26	79.28 ± 34.36	74.10 ± 20.73	0.130
GQE^#	4.02 ± 3.09	4.18 ± 2.48	4.38 ± 3.46	3.31 ± 2.41	0.002
Rate of GQE (%)	56.78 ± 27.49	56.99 ± 23.66	57.08 ± 29.04	56.09 ± 27.38	0.964
Paternal age (years)^#	40.35 ± 6.12	31.05 ± 4.13	40.25 ± 4.49	44.24 ± 5.29	0.001
Sperm concentration (10^6/ml)^#	55.45 ± 38.67	43.80 ± 51.14	59.57 ± 36.16	52.43 ± 36.26	0.006
PR (%)	46.08 ± 18.73	46.11 ± 22.41	46.01 ± 17.93	46.21 ± 18.70	0.994
Rate of normal morphological sperm (%)^#	4.52 ± 1.29	3.59 ± 1.70	4.70 ± 1.09	4.57 ± 1.28	0.001
SDFI (%)	23.48 ± 15.57	22.30 ± 12.48	23.84 ± 17.12	23.39 ± 13.75	0.780

BMI, body mass index; AFC, antral follicle count; AMH, anti-Müllerian hormone; ORPI, ovarian response prediction index; FSH, follicle-stimulating hormone; LH, luteinizing hormone; E2, estradiol; TT, total testosterone; NOR, numbers of oocytes retrieved; GQE, numbers of good-quality embryos; SDFI, sperm DNA fragmentation index; PR, progressive motility (sperm); SD, standard deviation. P value for the comparison between the three age subgroups. ^#Multiple comparisons between the different two subgroups. Duration of infertility: group 1 vs. group 3 (); AFC, AMH/age ratio, AFC/age ratio, ORPI, and paternal age: all ; AMH: group 1 vs. group 3 (), group 2 vs. group 3 (); NRO and GQE: group 2 vs. group 3 (, , respectively); sperm concentration: group 1 vs. group 2 (); normal morphology: group 1 vs. group 2 and group 1 vs. group 3 (all ).