Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An Insight from the China H-Type Hypertension Registry Study
Table 1
Clinical characteristics of the study population according to the TyG index.
Q1 (7.13–8.44)
Q2 (8.45–8.82)
Q3 (8.83–9.24)
Q4 (9.25–12.22)
P value
N
3254
3263
3261
3282
Age (y)
66.42 ± 9.38
64.73 ± 9.38
63.03 ± 9.16
61.08 ± 9.10
<0.001
Male, n (%)
2167 (62.72)
1709 (47.43)
1423 (40.22)
1367 (38.67)
<0.001
Education, n (%)
<0.001
<High school
2456 (92.68)
2443 (93.07)
2387 (91.14)
2451 (90.04)
≥High school
194 (7.32)
182 (6.93)
232 (8.86)
271 (9.96)
Current smoking, n (%)
1157 (35.57%)
870 (26.66%)
688 (21.10%)
734 (22.37%)
<0.001
Current drinking, n (%)
948 (29.14%)
714 (21.89%)
615 (18.87%)
648 (19.75%)
<0.001
BMI (kg/m2)
21.81 ± 4.10
23.03 ± 3.54
24.07 ± 3.28
25.09 ± 3.22
<0.001
Waist circumference (cm)
78.55 ± 9.06
82.17 ± 9.49
85.24 ± 9.54
88.07 ± 8.63
<0.001
Physical activity, n (%)
0.688
Mild
1767 (66.68)
1759 (67.01)
1708 (65.22)
1824 (67.01)
Moderate
652 (24.60)
631 (24.04)
684 (26.12)
658 (24.17)
Vigorous
231 (8.72)
235 (8.95)
227 (8.67)
240 (8.82)
SBP (mmHg)
147.48 ± 18.20
148.82 ± 17.66
148.43 ± 17.35
149.53 ± 18.10
<0.001
DBP (mmHg)
87.50 ± 11.01
88.67 ± 10.69
89.26 ± 10.47
91.23 ± 10.67
<0.001
Fasting glucose (mmol/L)
5.45 ± 0.60
5.77 ± 0.71
6.02 ± 0.91
6.88 ± 2.07
<0.001
Total cholesterol (mmol/L)
4.68 ± 0.94
5.10 ± 0.95
5.36 ± 1.06
5.58 ± 1.21
<0.001
Triglyceride (mmol/L)
0.82 ± 0.17
1.25 ± 0.18
1.77 ± 0.30
3.26 ± 1.57
<0.001
Serum homocysteine, μmol/L
18.25 ± 11.19
18.58 ± 11.89
17.58 ± 10.77
17.63 ± 10.46
<0.001
HDL-C (mmol/L)
1.74 ± 0.46
1.64 ± 0.41
1.54 ± 0.38
1.40 ± 0.37
<0.001
LDL-C (mmol/L)
2.54 ± 0.65
2.92 ± 0.68
3.19 ± 0.76
3.33 ± 0.85
<0.001
eGFR (ml/min per 1.73 m2)
87.66 ± 20.06
88.08 ± 19.86
89.11 ± 19.45
89.07 ± 20.21
0.005
TyG index
8.15 ± 0.23
8.64 ± 0.11
9.02 ± 0.12
9.68 ± 0.39
<0.001
Serum uric acid, μmol/L
398.34 ± 112.00
406.44 ± 116.60
419.19 ± 118.91
452.41 ± 127.58
<0.001
Hyperuricemia, n (%)
1225 (37.65%)
1324(40.58%)
1457 (44.68%)
1846 (56.25%)
<0.001
Diabetes, n (%)
86 (2.64%)
230 (7.05%)
399 (12.24%)
1061 (32.33%)
<0.001
Antihypertensive drugs, n (%)
1980 (60.87%)
2095 (64.20%)
2069 (63.47%)
2131 (64.95%)
0.004
Antiplatelet drugs, n (%)
65 (2.0%)
73 (2.24%)
65 (1.99%)
68 (2.07%)
0.890
Values are N (%), mean ± SD. BMI: body mass index (calculated as weight in kilograms divided by height in meters squared); SBP: systolic blood pressure; DBP: diastolic blood pressure; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; eGFR: estimated glomerular filtration rate; TyG: triglyceride-glucose.
