Paeoniflorin Ameliorates Hyperprolactinemia-Induced Inhibition of Osteoblastogenesis by Suppressing the NF-<i>κ</i>B Signaling Pathway

<div>Prolactin inhibited osteoblast differentiation in vitro. (a) A CCK-8 assay was performed to evaluate cell viability. (b) Representative images of ALP and ARS staining. (c) The ALP-positive cells in each group were quantified. (d) Quantification of ARS-stained cells and mineral nodules. n = 3; scale bar = 200 <i>μ</i>m; <svg height="11.5773pt" id="M1" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.5275 5.04606 11.5773" width="5.04606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g></svg> <svg height="9.2729pt" id="M2" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 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ALP, alkaline phosphatase; ARS, alizarin red S.</div>

International Journal of Endocrinology

fig1

Figure 1

Figure 1: Paeoniflorin Ameliorates Hyperprolactinemia-Induced Inhibition of Osteoblastogenesis by Suppressing the NF-<i>κ</i>B Signaling Pathway 

International Journal of Endocrinology

Paeoniflorin Ameliorates Hyperprolactinemia-Induced Inhibition of Osteoblastogenesis by Suppressing the NF-κB Signaling Pathway

Figure 1