Research Article

ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway

Figure 4

ASPM regulates the Wnt/β-catenin signaling pathway in ATC cells. (a) Wnt3a was detected by TOPFlash assay, and several representative targets of Wnt signaling (CCND1, c-Jun, MMP7, and c-MYC) were evaluated using western blotting. (b) The expression of β-catenin in ATC cells after co-transfection with sh-ASPM and human β-catenin plasmids. (c–f) Cell proliferation, migration, and invasion were re-evaluated after the rescue of β-catenin. , .
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