Change in Antithyroglobulin Antibody Levels is a Good Predictor of Responses to Therapy in Antithyroglobulin Antibody-Positive Pediatric Papillary Thyroid Carcinoma Patients

Table 4

Univariate analysis for clinicopathologic factors associated with responses to therapy in P-Tg groups.

	No. of patients	Acceptable	Unacceptable
Age at diagnosis of DTC
≤15	4 (23.53%)	(30.00%)	1 (14.29%)	0.864
>15	13 (76.47%)	(70.00%)	6 (85.71%)
Sex
Female	17 (100.0%)	10 (100.00%)	7 (100.00%)
Number of thyroid surgeries
1	13 (76.47%)	9 (90.0%)	4 (57.14%)	0.322
>1	4 (23.53%)	1 (10.0%)	3 (42.86%)
Tumor diameter (cm)
≤2	7 (41.18%)	5 (50.0%)	2 (28.57%)	0.529
>2, ≤4	7 (41.18%)	4 (40.0%)	3 (42.86%)
>4	3 (17.64%)	1 (10.0%)	2 (28.57%)
Multiplicity
Single	9 (52.94%)	6 (60.0%)	3 (42.86%)	0.839
Multiple	8 (47.16%)	4 (40.0%)	4 (57.14%)
Extra-thyroidal extension
No	9 (52.94%)	8 (80.0%)	1 (14.29%)	0.029
Minimal/gross	8 (47.16%)	2 (20.0%)	6 (85.71%)
N stage
N0 or Nx	1 (5.88%)	0 (0%)	1 (14.29%)	0.100
N1a	4 (23.53%)	4 (40.0%)	0 (0%)
N1b	12 (70.59%)	6 (60.0%)	6 (85.71%)
Initial risk stratification
Low/intermediate	7 (41.18%)	7 (70.0%)	0 (0%)	0.017
High	10 (58.82%)	3 (30.0%)	7 (100.0%)
With LT
No	9 (52.94%)	5 (50.0%)	3 (42.86%)	1.000
Yes	8 (47.16%)	5 (50.0%)	4 (57.14%)
Number of courses for ^131I therapy
1	13 (76.47%)	8 (80.0%)	5 (71.43%)	1.000
>1	4 (23.53%)	2 (20.0%)	2 (28.57%)
Cumulative dose of ^131I activities (mCi)
≤100	12 (70.59%)	8 (80.0%)	4 (57.14%)	0.633
>100	5 (29.41%)	2 (20.0%)	3 (42.86%)
sTg (ng/ml)
<1	7 (41.18%)	4 (40.0%)	3 (42.86%)	1.000
≥1	10 (58.82%)	6 (60.0%)	4 (57.14%)
sTgAb (IU/ml)
<500	11 (64.71%)	8 (80.0%)	3 (42.86%)	0.288
≥500	6 (35.29%)	2 (20.0%)	4 (57.14%)
TgAb trend
Decrease >50%	11 (64.71%)	9 (90.0%)	2 (28.57%)	0.036
Decrease <50% or increase	6 (35.29%)	1 (10.0%)	5 (71.43%)
TgAb tends to be negative
Yes	8 (47.06%)	3 (30.0%)	5 (71.43%)	0.234
No	9 (52.94%)	7 (70.0%)	2 (28.57%)
Tg trend
Decrease ≥50%	11 (64.71%)	9 (90.0%)	2 (28.57%)	0.036
Decrease <50% or increase	6 (35.29%)	1 (10.0%)	5 (71.43%)
Tg tends to be negative
Yes	7 (41.18%)	2 (20.0%)	5 (71.43%)	0.105
No	10 (58.82%)	8 (80.0%)	2 (28.57%)

sTg, stimulated Tg; sTgAb, stimulated TgAb; N, lymph node; LT, lymphocytic thyroiditis. .