Change in Antithyroglobulin Antibody Levels is a Good Predictor of Responses to Therapy in Antithyroglobulin Antibody-Positive Pediatric Papillary Thyroid Carcinoma Patients
Table 5
Univariate analysis for clinicopathologic factors associated with responses to therapy in N-Tg groups.
No. of patients
Acceptable
Unacceptable
Age at diagnosis of DTC
≤15
9 (29.03%)
4 (22.22%)
5 (38.46%)
0.433
>15
22 (70.97%)
14 (77.78%)
8 61.54%)
Sex
Female
27 (100.0%)
15 (83.33%)
12 (92.31%)
0.847
Male
4 (100.0%)
3 (16.67%)
1 (7.69%)
Number of thyroid surgeries
1
27 (87.10%)
15 (83.33%)
12 (92.30%)
0.621
>1
4 (12.90%)
3 (16.67%)
1 (7.69%)
Tumor diameter (cm)
≤2
17 (54.84%)
10 (55.56%)
7 (53.85%)
0.983
>2, ≤4
9 (29.03%)
5 (27.78%)
4 (30.77%)
>4
5 (16.13%)
3 (16.67%)
2 (15.38%)
Multiplicity
Single
17 (54.84%)
10 (55.56%)
3 (53.85%)
0.925
Multiple
14 (45.16%)
8 (44.44%)
4 (46.15%)
Extra-thyroidal extension
No
22 (71.97%)
16 (88.89%)
6 (46.15%)
0.029
Minimal/gross
9 (29.03%)
2 (11.11%)
7 (53.85%)
N stage
N0 or Nx
3 (9.68%)
2 (11.11%)
1 (7.69%)
0.171
N1a
7 (22.58%)
4 (22.22%)
3 (23.08%)
N1b
21 (67.74%)
12 (66.67%)
9 (69.23%)
Initial risk stratification
Low/intermediate
19 (63.29%)
15 (83.33%)
4 (30.78%)
0.003
High
12 (38.71%)
3 (16.67%)
9 (69.23%)
With LT
No
17 (54.84%)
8 (44.44%)
9 (69.23%)
0.171
Yes
14 (45.16%)
10 (55.56%)
4 (30.78%)
Number of courses for 131I therapy
1
27 (87.09%)
16 (88.89%)
11 (84.62%)
1.000
>1
4 (12.90%)
2 (11.11%)
2 (15.38%)
Cumulative dose of 131I activities (mCi)
≤100
25 (80.65%)
16 (88.89%)
9 (69.23%)
0.365
>100
6 (19.35%)
2 (11.11%)
4 (30.78%)
sTg (ng/ml)
<1
25 (80.65%)
15 (83.33%)
10 (76.92%)
1.000
≥1
6 (19.35%)
3 (16.67%)
3 (23.08%)
sTgAb (IU/ml)
<500
16 (51.61%)
11 (61.11%)
5 (38.46%)
0.288
≥500
15 (48.39%)
7 (38.89%)
8 (61.54%)
TgAb trend
Decrease ≥50%
18 (64.71%)
16 (88.89%)
2 (15.38%)
<0.001
Decrease <50% or increase
13 (35.29%)
2 (11.11%)
11 (84.62%)
TgAb tends to be negative
Yes
17 (54.84%)
5 (27.78%)
5 (92.31%)
<0.001
No
14 (45.16%)
13 (72.22%)
2 (7.69%)
sTg, stimulated Tg; sTgAb, stimulated TgAb; N, lymph node; LT, lymphocytic thyroiditis. p < 0.05.
