Potential Role of TRPV4 in Stretch-Induced Ghrelin Secretion and Obesity

<div>Regulation of ghrelin secretion by mechanical stimuli in MGN3-1 cells (ELISA). Cells were subjected to a 120% stretch nine times for 3 min twice. This stretch protocol was repeated 2 hours later. After 4 hours, acyl ghrelin and des-acyl ghrelin were measured by the ELISA. (a) Unstretched MGN3-1 cells. (b) 120% stretch of MGN3-1 cells. (c) The amount of acyl ghrelin in the supernatant obtained after 120% stretch and treatment of MGN3-1 cells with HC067047 (20 <i>μ</i>M) + 120% stretch. (d) The amount of des-acyl ghrelin in the supernatant obtained after 120% stretch and treatment of MGN3-1 cells with HC067047 (20 <i>μ</i>M) + 120% stretch. 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International Journal of Endocrinology

fig6

Figure 6

Figure 6: Potential Role of TRPV4 in Stretch-Induced Ghrelin Secretion and Obesity 