Clinical Implications of Age in Differentiated Thyroid Cancer: Comparison of Clinical Outcomes between Children and Young Adults
Table 1
Comparison of clinicopathological characteristics among groups.
<20 years old (A) (n = 98)
20–29 years old (B) (n = 1261)
30–39 years old (C) (n = 4017)
value (A versus B)
value (A versus C)
Age (years)
16.7 ± 3.0
26.2 ± 2.5
34.8 ± 2.8
<0.001
<0.001
Male : female
1 : 7.9
1 : 7.2
1 : 5.2
0.873
0.211
Male
11 (11.2%)
153 (12.1%)
650 (16.2%)
Female
87 (88.8%)
1108 (87.9%)
3367 (83.8%)
Tumor size (cm)
2.1 ± 1.3
1.3 ± 1.0
1.0 ± 0.8
<0.001
<0.001
Type of carcinoma
0.002
<0.001
PTC
91 (92.9%)
1241 (98.4%)
3989 (99.3%)
FTC
7 (7.1%)
20 (1.6%)
28 (0.7%)
Multifocality
24 (24.5%)
284 (22.5%)
975 (34.3%)
0.619
0.520
Bilaterality
15 (15.3%)
173 (13.7%)
592 (14.7%)
0.649
0.885
ETE
36 (36.7%)
359 (28.5%)
610 (15.2%)
0.402
0.153
T stage
<0.001
<0.001
T1
44 (44.9%)
815 (64.7%)
3248 (80.9%)
T2
17 (17.3%)
85 (6.7%)
154 (3.8%)
T3
33 (33.7%)
342 (27.1%)
558 (13.9%)
T4
4 (4.1%)
19 (1.5%)
57 (1.4%)
N stage
<0.001
<0.001
N0
25 (25.5%)
577 (45.8%)
2255 (56.2%)
N1a
43 (43.9%)
454 (36.0%)
1331 (33.1%)
N1b
30 (30.6%)
230 (18.2%)
431 (10.7%)
M stage
0.064
0.018
M1
2 (2.0%)
4 (0.3%)
7 (0.2%)
Recurrence
14 (14.3%)
83 (6.6%)
121 (3.0%)
0.004
<0.001
Data are expressed as patient’s number (%) or mean ± SD. A statistically significant difference was defined as . PTC, papillary thyroid carcinoma; FTC, follicular thyroid carcinoma; ETE, extrathyroidal extension; T, tumor; N, node; M, metastasis.
