Clinical Implications of Age in Differentiated Thyroid Cancer: Comparison of Clinical Outcomes between Children and Young Adults

Table 3

Univariate and multivariate analyses for DFS in different age groups.

	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Age (years)
< 20	Ref.		Ref.
20–29	0.437 (0.252–0.757)	0.003	0.599 (0.345–1.040)	0.069
30–39	0.210 (0.123–0.359)	<0.001	0.362 (0.210–0.625)	<0.001
Tumor size
≤1 cm	Ref.		Ref.
>1 cm	3.354 (2.509–4.484)	<0.001	2.272 (1.673–3.086)	<0.001
ETE	1.752 (1.332–2.303)	<0.001
Multifocality	1.495 (1.124–1.988)	0.006
Bilaterality	1.837 (1.346–2.508)	<0.001
T stage
T1	Ref.
T2	2.267 (1.244–4.131)	0.008
T3	1.950 (1.448–2.627)	<0.001
T4	4.860 (2.564–9.213)	<0.001
N stage
N0	Ref.	-	Ref.	-
N1a	2.596 (1.862–3.619)	<0.001	2.074 (1.477–2.911)	<0.001
N1b	5.129 (3.613–7.283)	<0.001	3.267 (2.256–4.732)	<0.001
RAI therapy
No	Ref.	-
yes	1.709 (1.303–2.244)	<0.001

Data are expressed as hazard ratio (HR) and 95% confidence interval (CI). A statistically significant difference was defined as . ETE, extrathyroidal extension; T, tumor; N, node; RAI, radioactive iodine.