Clinical Implications of Age in Differentiated Thyroid Cancer: Comparison of Clinical Outcomes between Children and Young Adults
Table 6
Subanalysis of clinicopathological characteristics of groups over 16 years of age.
17–19 years (A) (n = 61)
20–29 years old (B) (n = 1261)
30–39 years old (C) (n = 4017)
value (A versus B)
value (A versus C)
Age (years)
18.4 ± 0.8
26.2 ± 2.5
34.8 ± 2.8
<0.001
<0.001
Male : female
1 : 14.3
1 : 7.2
1 : 5.2
0.227
0.051
Male
4 (6.6%)
153 (12.1%)
650 (16.2%)
Female
57 (93.4%)
1108 (87.9%)
3367 (83.8%)
Tumor size (cm)
1.9 ± 1.5
1.3 ± 1.0
1.0 ± 0.8
<0.001
<0.001
Type of carcinoma
0.001
<0001
PTC
55 (90.2%)
1241 (98.4%)
3989 (99.3%)
FTC
6 (9.8%)
20(1.6%)
28(0.7%)
Multifocality
14 (23.0%)
284(22.5%)
975(34.3%)
0.938
0.881
Bilaterality
7 (11.5%)
173(13.7%)
592(14.7%)
0.848
0.586
ETE
17 (27.9%)
359 (28.5%)
610 (15.2%)
0.432
0.699
T stage
0.001
<0.001
T1
34 (55.7%)
815 (64.7%)
3248 (80.9%)
T2
9 (14.8%)
85 (6.7%)
154 (3.8%)
T3
17 (27.9%)
342 (27.1%)
558 (13.9%)
T4
1 (1.6%)
19 (1.5%)
57 (1.4%)
N stage
0.039
<0.001
N0
18 (29.5%)
577 (45.8%)
2255 (56.2%)
N1a
33 (54.1%)
454 (36.0%)
1331 (33.1%)
N1b
10 (16.4%)
230 (18.2%)
431 (10.7%)
M stage
0.211
0.114
M1
1 (1.6%)
4 (0.3%)
7 (0.2%)
Recurrence
8 (13.1%)
83 (6.6%)
121 (3.0%)
0.064
0.001
Data are expressed as patient’s number (%) or mean ± SD. A statistically significant difference was defined as . PTC, papillary thyroid carcinoma; FTC, follicular thyroid carcinoma; ETE, extrathyroidal extension; T, tumor; N, node; M, metastasis.
