Clinical Implications of Age in Differentiated Thyroid Cancer: Comparison of Clinical Outcomes between Children and Young Adults

Table 8

Univariate and multivariate analyses for DFS in different age groups.

	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Age (years)
17–19	Ref.		Ref.
20–29	0.477 (0.242–0.826)	0.046	0.561 (0.337–1.117)	0.156
30–39	0.230 (0.110–0.387)	<0.001	0.362 (0.206–0.627)	0.006
Tumor size
≤1 cm	Ref.		Ref.
>1 cm	3.228 (2.411–4.648)	<0.001	2.417 (1.594–3.163)	<0.001
ETE	1.704 (1.295–2.412)	<0.001
Multifocality	1.427 (1.103–1.864)	0.006
Bilaterality	1.801 (1.294–2.576)	<0.001	1.470 (0.954–1.932)	0.026
T stage
T1	Ref.
T2	2.346 (1.216–4.215)	0.005
T3	1.936 (1.426–2.518)	<0.001
T4	4.195 (2.286–8.639)	<0.001
N stage
N0	Ref.	-	Ref.	-
N1a	2.692 (1.749–3.943)	<0.001	2.349 (1.256–2.984)	<0.001
N1b	5.095 (3.437–7.842)	<0.001	4.046 (2.547–5.438)	<0.001
RAI therapy
No	Ref.	-
yes	1.785 (1.203–2.548)	<0.001

Data are expressed as hazard ratio (HR) and 95% confidence interval (CI). A statistically significant difference was defined as . ETE, extrathyroidal extension; T, tumor; N, node; RAI, radioactive iodine.