Development of a Novel Algorithm to Identify People with High Likelihood of Adult Growth Hormone Deficiency in a US Healthcare Claims Database
Table 2
Comorbidities of the study cohort by the likelihood of having AGHD.
Likelihood of having AGHD (%)
Standardized difference
High
Moderate
Low
High vs low
High vs moderate
Moderate vs low
Cardiovascular
Cerebrovascular disease
3.7
1.8
0.8
−0.14
−0.08
−0.06
Hypertensive disorder
31.4
25.9
14.6
−0.25
−0.07
−0.18
Heart disease
15.6
10.7
5.4
−0.22
−0.09
−0.13
Atrial fibrillation
1.9
1.2
0.6
−0.08
−0.04
−0.04
Coronary arteriosclerosis
4.6
3.1
1.8
−0.11
−0.05
−0.06
Heart failure
2.0
1.1
0.6
−0.09
−0.05
−0.04
Ischemic heart disease
2.7
1.8
1.0
−0.09
−0.04
−0.05
Peripheral vascular disease
1.5
1.1
2.2
0.04
−0.03
0.06
Pulmonary embolism or venous thrombosis
2.5
1.1
0.5
−0.12
−0.07
−0.05
Endocrine/metabolic/nutrition
Anorexia nervosa or malnutrition
0.6
0.3
0.1
−0.07
−0.04
−0.03
Diabetes mellitus or impaired glucose tolerance
14.1
11.8
5.7
−0.20
−0.05
−0.15
Hyperlipidemia
32.6
28.8
14.6
−0.26
−0.05
−0.22
Metabolic syndrome X
1.3
1.4
0.3
−0.08
0.01
−0.09
Obesity
9.4
9.9
3.7
−0.16
0.01
−0.17
Musculoskeletal
Osteoarthritis
17.1
14.9
6.2
−0.23
−0.04
−0.19
Osteoporosis
3.8
2.0
0.8
−0.14
−0.08
−0.07
Neoplasms
Hematologic neoplasm
4.5
0.8
0.3
−0.19
−0.16
−0.05
Neoplasm of thyroid gland
1.4
0.7
0.2
−0.10
−0.05
−0.06
Neoplasm of bone
2.2
0.3
0.1
−0.13
−0.12
−0.02
Malignant neoplastic diseasea
23.9
5.7
2.5
−0.42
−0.34
−0.11
Malignant lymphoma
1.6
0.3
0.1
−0.11
−0.09
−0.03
Malignant tumor of breast
8.8
1.3
0.5
−0.27
−0.24
−0.06
Malignant tumor of colon
1.2
0.2
0.1
−0.09
−0.09
−0.01
Malignant tumor of lung
2.1
0.2
0.1
−0.13
−0.13
−0.01
Primary malignant neoplasm of prostate
1.7
0.5
0.3
−0.10
−0.08
−0.03
Renal
Renal impairment
3.5
2.0
0.9
−0.13
−0.06
−0.06
Respiratory
Acute respiratory disease
30.2
29.6
20.1
−0.14
−0.01
−0.14
Chronic obstructive lung disease
3.6
1.8
1.0
−0.12
−0.08
−0.05
Pneumonia
3.4
1.7
1.0
−0.11
−0.08
−0.04
Other
Dementia
0.5
0.3
0.1
−0.04
−0.02
−0.02
Depressive disorder
13.9
13.3
5.6
−0.19
−0.01
−0.18
Visual system disorder
23.9
19.0
11.0
−0.22
−0.08
−0.15
aMalignant neoplastic disease comprises malignant lymphoma; malignant neoplasms of anorectum, breast, colon, lung, or urinary bladder; or primary malignant neoplasm of prostate. %, percentage of people from the respective likelihood group; AGHD, adult growth hormone deficiency.
