Research Article

Low Serum Total Testosterone Is Associated with Non-Alcoholic Fatty Liver Disease in Men but Not in Women with Type 2 Diabetes Mellitus

Table 3

Odds ratios of NAFLD among men by different types of androgens.

Odds ratios (95% CI)
Model 1Model 2Model 3Model 4

TT
 Tertile11111
 Tertile20.76 (0.48, 1.20)0.77 (0.48, 1.21)0.70 (0.35, 1.40)0.68 (0.33, 1.38)
 Tertile30.36 (0.23, 0.57)0.37 (0.24, 0.58)0.38 (0.19, 0.77)0.37 (0.17, 0.77)
 P for trend<0.001<0.0010.0180.024
 Per SD increment0.61 (0.50, 0.73)0.61 (0.51, 0.74)0.58 (0.42, 0.79)0.58 (0.42, 0.80)

Androstenedione
 Tertile11111
 Tertile20.72 (0.47, 1.10)0.74 (0.48, 1.14)0.74 (0.40, 1.38)0.76 (0.38, 1.54)
 Tertile30.89 (0.57, 1.39)0.93 (0.59, 1.45)0.89 (0.46, 1.72)0.97 (0.43, 2.18)
 P for trend0.3070.3490.6340.683
 Per SD increment0.93 (0.77, 1.11)0.93 (0.78, 1.12)0.90 (0.68, 1.18)0.91 (0.63, 1.30)

DHEA
Tertile11111
 Tertile20.84 (0.54, 1.28)0.87 (0.56, 1.34)0.92 (0.50, 1.72)1.13 (0.56, 2.29)
 Tertile30.83 (0.50, 1.36)0.85 (0.51, 1.40)1.11 (0.53, 2.33)1.57 (0.57, 4.29)
 P for trend0.6640.7570.8860.671
 Per SD increment0.98 (0.78, 1.24)0.97 (0.77, 1.23)1.03 (0.73, 1.47)1.22 (0.71, 2.09)

DHEAS
 Tertile11111
 Tertile21.36 (0.89, 2.07)1.37 (0.89, 2.09)1.73 (0.93, 3.21)1.48 (0.77, 2.88)
 Tertile31.14 (0.70, 1.84)1.14 (0.70, 1.85)1.08 (0.51, 2.27)0.81 (0.33, 2.00)
 P for trend0.3700.3520.1790.239
 Per SD increment1.07 (0.86, 1.33)1.06 (0.85, 1.32)1.13 (0.79, 1.61)0.99 (0.65, 1.52)

Model 1: adjusted for age. Model 2: adjusted for model 1 + current smoking and current drinking. Model 3: adjusted for model 2 + BMI, duration of T2DM, diastolic blood pressure, TC, TG, LDL/HDL cholesterol ratio, UA, and CRP. Model 4: adjusted for model 3, but mutually for hormones. NAFLD, non-alcoholic fatty liver disease; CI, confidence interval; SD, standard deviation; BMI, body mass index; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; UA, uric acid; CRP, C-reactive protein; TT, total testosterone; DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulfate.