Association between Serum Copper, Selenium, Zinc, and Serum Estradiol in Women

Table 4

Association between serum selenium (μmol/L) and E2 (ng/mL).

	Model 1 β (95% CI) -value	Model 2 β (95% CI) -value	Model 3 β (95% CI) -value
Total	−92.971 (−145.950, −39.992) 0.00059	−68.020 (−121.724, −14.317) 0.01311	−56.811 (−109.592, −4.030) 0.03499
Age
Total	−67.795 (−120.985, −14.604) 0.01255	−68.372 (−121.631, −15.112) 0.01193	−60.032 (−112.783, −7.282) 0.02580
<25	−63.838 (−122.896, −4.779) 0.03443	−60.788 (−119.757, −1.819) 0.04367	−62.849 (−113.010, −12.687) 0.01427
25-55	−139.035 (−269.373, −8.697) 0.03682	−148.320 (−279.474, −17.166) 0.02690	−141.971 (−273.296, −10.647) 0.03437
56	−2.150 (−7.463, 3.163) 0.42796	−1.366 (−6.672, 3.939) 0.61395	0.344 (−4.915, 5.603) 0.89803
Race/Hispanic origin
Total	−89.588 (−142.588, −36.588) 0.00094	−68.020 (−121.724, −14.317) 0.01311	−56.811 (−109.592, −4.030) 0.03499
Mexican American	−339.806 (−619.704, −59.908) 0.01773	−333.846 (−622.363, −45.329) 0.02379	−364.527 (−652.132, −76.922)0.01334
Other Hispanic	−260.025 (−547.437, 27.387) 0.07719	−231.269 (−528.116, 65.579) 0.12780	−258.957 (−563.502, 45.588) 0.09667
Non-Hispanic white	−44.632 (−79.351, −9.913) 0.01194	−25.603 (−59.777, 8.571) 0.14238	−15.821 (−48.087, 16.445) 0.33683
Non-Hispanic black	−55.100 (−211.408, 101.207) 0.48997	−31.168 (−187.715, 125.379) 0.69655	−61.797 (−210.473, 86.878) 0.41571
Other race—including multiracial	−78.140 (−122.419, −33.861) 0.00061	−52.470 (−99.049, −5.891) 0.02790	−9.188 (−51.084, 32.707) 0.66757

Model 1: no covariates were adjusted. Model 2: age and race were adjusted. Model 3: age, race, education, ratio of family income to poverty, testosterone, total, body mass index, and marital status were adjusted. In the subgroup analysis stratified by age and race, the model was not adjusted for age and race.