Review Article
Leptin Levels in Serum or Semen and Its Association with Male Infertility: A Meta-Analysis with 1138 Cases
Table 2
The characteristics of 12 eligible studies providing seminal leptin concentration.
| | Year | Country | Control | Case | Language | Method | | Total (n) | Leptin (ug/L) | Age (y) | BMI | Sperm concentration (106/mL) | Sperm progressive motility (%) | Total (n) | Leptin (ug/L) | Age (y) | BMI | Sperm concentration (106/mL) | Sperm progressive motility (%) |
| | 2014 | China | 40 | 1.69 ± 0.11 | 28.83 ± 5.35 | 22.41 ± 1.28 | 21.86 ± 2.57 | 82.62 ± 4.23 | 74 | 3.2 ± 0.31 | 29.76 ± 13.18 | 22.31 ± 0.85 | 17.98 ± 3.60 | 37.31 ± 8.08 | English | RIA | | 2014 | China | 77 | 3.75 ± 0.97 | 31.1 ± 2.7 | 24.32 ± 2.14 | 41.84 ± 11.39 | 48.73 ± 7.27 | 79 | 4.72 ± 0.99 | 30.9 ± 2.7 | 24.15 ± 2.13 | 33.47 ± 11.08 | 20.42 ± 5.78 | English | ELISA | | 2003 | Germany | 21 | 0.21 ± 0.21 | 33 ± 4 | 23 ± 3 | 88.31 ± 41.81 | ≥50 | 13 | 0.54 ± 0.41 | 33 ± 4 | 23 ± 3 | 0 | 0 | English | RIA | | 2011 | China | 30 | 1.69 ± 0.2 | 29.8 ± 0.57 | 21.83 ± 1.36 | ≥15 | ≥32 | 45 | 4.8 ± 1.07 | 29.56 ± 0.77 | 23.45 ± 0.57 | 0 | 0 | Chinese | RIA | | 2015 | China | 62 | 0.96 ± 0.42 | 32.8 ± 6.2 | N/A | ≥15 | ≥32 | 76 | 2.39 ± 0.81 | 33.4 ± 5.9 | N/A | <15 | N/A | Chinese | ELISA | | 2007 | China | 30 | 5.29 ± 2.11 | 30.3 ± 4.2 | <25 | N/A | N/A | 126 | 6.3 ± 2.79 | 30.4 ± 4.0 | <25 | N/A | N/A | Chinese | RIA | | 2016 | Iran | 95 | 0.65 ± 0.38 | 34.12 ± 5.3 | 24.15 ± 3.8 | 27.6 ± 16.5 | 22.98 ± 18.9 | 98 | 0.56 ± 0.4 | 34.14 ± 6.2 | 24.17 ± 4.42 | 9.45 ± 8 | 22.51 ± 11.64 | English | ELISA | | 2002 | Germany | 28 | 1.5 ± 0.2 | N/A | 25.45 ± 2.45 | 86.3 ± 15.2 | 31.9 ± 2.6 | 36 | 3.19 ± 0.6 | N/A | 25.60 ± 2.46 | 23.6 ± 4.1 | 18.1 ± 1.9 | English | RIA | | 2014 | China | 40 | 1.58 ± 0.23 | 27.69 ± 6.53 | 21.91 ± 0.76 | 26.29 ± 9.40 | 54.85 ± 9.76 | 80 | 2.81 ± 1.09 | 28.16 ± 7.62 | 22.92 ± 0.42 | 18.16 ± 8.87 | 25.23 ± 12.72 | Chinese | RIA | | 2014 | South Africa | 19 | 5.6 ± 3.8 | 35.1 ± 5.9 | 25.5 ± 2.4 | 35.3 ± 16.7 | 33.8 ± 16.2 | 23 | 12.9 ± 9.1 | 37.9 ± 7.3 | 35.8 ± 4.3 | 23.7 ± 13.6 | 24.5 ± 19.1 | English | ELISA | | 2010 | Egypt | 42 | 7.93 ± 0.05 | 29.79 ± 1.1 | 31.21 ± 0.39 | 51.57 ± 6.70 | 57.50 ± 1.41 | 80 | 12.36 ± 0.17 | 29.35 ± 0.9 | 33.49 ± 0.43 | 12.97 ± 1.55 | 13.25 ± 0.79 | English | ELISA |
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ELISA: enzyme-linked immunosorbent assay; RIA: radioimmunoassay; N/A: negative.
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