Relationship between Uric Acid to High Density Lipoprotein Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Nonoverweight/Obese Patients with Type 2 Diabetes
Table 1
Clinical and biochemical characteristics of study subjects and the differences of factors between patients with non-NAFLD and NAFLD.
General indexes
All patients (n = 343)
NAFLD (n = 184)
Non-NAFLD (n = 159)
T/Z
Age (yr)
50.96 ± 11.67
50.85 ± 11.70
51.08 ± 11.66
0.18
>0.05
BMI (kg/m2)
22.68 (21.80–23.30)
22.94 (22.20–23.45)
22.21 (20.70–22.96)
−5.72
<0.001
SBP (mmHg)
131.94 ± 17.68
135.19 ± 17.88
128.18 ± 16.74
−3.71
<0.001
DBP (mmHg)
81.89 ± 11.55
84.15 ± 11.14
79.27 ± 11.49
−3.97
<0.001
FINS (pmol/l)
29.54 (16.76–47.05)
33.93 (20.24–54.50)
24.02 (13.23–39.97)
−3.99
<0.001
ALT (IU/L)
19.4 (15–30.45)
24.5 (16.8–36.8)
16.9 (13–21.83)
−5.88
<0.001
AST (IU/L)
20.07 (16.3–25.7)
22 (17.4–29.1)
18.4 (15.08–23.33)
−4.15
<0.001
γ-GGT (IU/L)
29.25 (19.48–44.08)
33.6 (23.08–50.63)
22 (16.28–38.08)
−5.13
<0.001
TC (mmol/L)
5.14 ± 1.77
5.35 ± 2.10
4.89 ± 1.25
−2.42
<0.05
TG (mmol/L)
1.30 (0.87–1.93)
1.68 (1.22–2.46)
0.94 (0.72–1.35)
−8.85
<0.001
HDL (mmol/L)
1.15 ± 0.27
1.09 ± 0.23
1.22 ± 0.29
4.57
<0.001
LDL (mmol/L)
3.21 ± 0.89
3.32 ± 0.84
3.08 ± 0.92
−2.54
<0.05
FBG (mmol/L)
7.92 (6.26–10.28)
8.53 (6.59–10.80)
7.30 (6.01–9.93)
−2.72
<0.01
BUN (mmol/L)
5.30 ± 1.47
5.21 ± 1.41
5.41 ± 1.54
1.22
>0.05
Cr (μmol/L)
63.88 ± 18.23
65.42 ± 16.01
62.11 ± 20.41
−1.67
>0.05
SUA (μmol/L)
287.58 ± 82.82
307.48 ± 80.22
264.56 ± 80.00
−4.94
<0.001
HOMA-IR
10.44 (5.53–18.32)
12.99 (6.96–20.97)
7.45 (4.30–13.62)
−4.69
<0.001
UHR (μmol/mmol)
264.14 ± 100.07
294.80 ± 99.90
228.67 ± 88.08
−6.45
<0.001
SBP: systolic pressure; DBP: diastolic pressure; FINS: fasting insulin ALT: alanine aminotransferase; AST: aspartate transferase; γ-GGT: γ-glutamyl transpeptidase; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FBG: fasting blood glucose; BUN: blood urea nitrogen; Cr: creatinine; SUA: serum uric acid; UHR: uric acid to HDL cholesterol ratio; HOMA-IR: insulin resistance index. The t test (for normal distribution) and Wilcoxon rank sum test (for skewed distribution) with different samples were adopted for comparison between groups. was considered as statistically significant difference.
