Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension: A Cross-Sectional Study

Table 3

Results of the univariate and multivariate linear regression between SUA and all parameters.

Variables	Univariate linear regression		Multivariate linear regression
	β coefficient (95% CI)	value	β coefficient (95% CI)	value
TyG index	38.61 (31.98–45.23)	<0.001	20.99 (14.19–27.8)	<0.001
Sex (female vs. male)	−77.72 (−84.81–−70.63)	<0.001	−50.14 (−59.77–−40.52)	<0.001
Age, years	−1.47 (−1.77–−1.17)	<0.001	−0.35 (−0.67–−0.03)	0.03
ALB, g/L	3.32 (2.32–4.32)	<0.001	2.09 (1.05–3.13)	<0.001
hs-CRP, mg/L	−0.52 (−1.02–−0.02)	0.04
LDL-C, mmol/L	−2.96 (−7.5–1.57)	0.2	−1.79 (−5.82–2.25)	0.39
TG, mmol/L	16.38 (13.15–19.6)	<0.001
HDL-C, mmol/L	−50.73 (−60.3–−41.15)	<0.001	−9.53 (−19.93–0.87)	0.07
ALT, U/L	1.06 (0.84–1.28)	<0.001	0.18 (−0.11–0.47)	0.22
AST, U/L	1.23 (0.87–1.6)	<0.001	0.55 (0.09–1.01)	0.02
Scr, μmol/L	1.77 (1.57–1.97)	<0.001	0.72 (0.33–1.11)	<0.001
BUN, U/L	10.12 (7.34–12.89)	<0.001	7.47 (5.06–9.89)	<0.001
Glucose, mmol/L	5.57 (1.45–9.69)	0.008
HCY, μmol/L	0.82 (0.33–1.32)	0.001
LPa, mg/dL	−0.04 (−0.06–−0.03)	<0.001	−0.01 (−0.03–0)	0.06
TC, mmol/L	0.1 (−3.67–3.87)	0.96
D-dimer, mg/L	−8.72 (−14.67–−2.77)	0.004	0.02 (−5.27–5.3)	0.995
INR	−20.83 (−57.42–15.75)	0.26	−7.61 (−40.08–24.86)	0.65
eGFR, mL/min per 1.73 m^2	−0.41 (−0.53–−0.28)	<0.001	−0.01 (−0.19–0.18)	0.96
Hypertension grades (3 vs. 1-2)	15.81 (7.86–23.75)	<0.001	11.58 (4.96–18.19)	0.001

SUA, serum uric acid; TyG, triglyceride-glucose index; ALB, serum albumin; hs-CRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Scr, blood creatinine; BUN, blood urea nitrogen; HCY, homocysteine; LPa, lipoprotein a; TC, total cholesterol; INR, international normalized ratio; and eGFR: estimated glomerular filtration rate. Statistically significant P-values in bold for a better follow-up of the results. The bold values mean that these parameters were associated with SUA in patients with primary hypertension (all P < 0.05). Furthermore, the multivariate analysis also revealed that the TyG index was positively associated with SUA after adjusting for potential confounding factors.