Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension: A Cross-Sectional Study

Table 5

Effect modification of TyG on HUA in different models, as stratified by grades of hypertension.

	Nonadjusted		Model 1		Model 2		Model 3
	OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value
Grades 1-2 hypertension
tTyG	3.19 (2.3–4.44)	<0.001	2.92 (2.09–4.08)	<0.001	2.79 (1.88–4.15)	<0.001	2.22 (1.44–3.42)	<0.001
Tertiles
Q1	1 (ref)		1 (ref)		1 (ref)		1 (ref)
Q2	2.83 (1.68–4.78)	<0.001	2.69 (1.59–4.54)	<0.001	2.67 (1.48–4.82)	0.001	2.57 (1.40–4.71)	0.002
Q3	4.90 (2.95–8.15)	<0.001	4.27 (2.55–7.15)	<0.001	3.97 (2.17–7.26)	<0.001	3.02 (1.57–5.82)	0.001
Trend. test	2.12 (1.68–2.68)	<0.001	1.98 (1.56–2.51)	<0.001	1.88 (1.42–2.5)	<0.001	1.63 (1.2–2.22)	0.002
Grade 3 hypertension
tTyG	1.98 (1.49–2.64)	<0.001	1.60 (1.19–2.17)	0.002	1.54 (1.12–2.12)	0.008	1.58 (1.11–2.24)	0.011
Tertiles
Q1	1 (ref)		1 (ref)		1 (ref)		1 (ref)
Q2	1.00 (0.62–1.63)	0.99	0.85 (0.52–1.4)	0.53	0.88 (0.52–1.5)	0.65	0.92 (0.53–1.58)	0.76
Q3	2.34 (1.53–3.59)	<0.001	1.78 (1.14–2.78)	0.01	1.88 (1.15–3.07)	0.01	1.99 (1.17–3.39)	0.01
Trend. test	1.60 (1.28–1.99)	<0.001	1.40 (1.11–1.76)	0.004	1.44 (1.12–1.84)	0.004	1.48 (1.13–1.94)	0.004
value for interaction
tTyG			0.01		0.03		0.03
Tertiles			0.008		0.02		0.02

Model 1 was adjusted for age; model 2 was adjusted for age, sex, ALB, ALT, AST, Scr, BUN, d-dimer, INR, eGFR, and hypertension grades; model 3 was adjusted for all covariables in model 2 plus LDL-C, HDL-C, and LPa. The enalapril group is the reference group. value for the interaction test: 2-way interaction of TyG (total TyG and TyG tertiles) and hypertension grades (grades 1-2 hypertension vs. grade 3 hypertension) with HUA. tTyG, total triglyceride-glucose index; other abbreviations are listed in Table 3. Statistically significant P-values in bold for a better follow-up of the results. The bold values mean that the differences are significant. And in the 1st -3rd tertiles, the TyG index had a strong significant association with HUA in the grades 1 -2 hypertension group compared to that in the grade 3 hypertension group (P for interaction <0.05).