International Journal of Endocrinology

Research Article

MAFLD in Patients with Cushing’s Disease Is Negatively Associated with Low Free Thyroxine Levels Rather than with Cortisol or TSH Levels

Table 2

Univariate and multivariate logistic regression analysis for the associations of MAFLD with hormones and the presence of metabolic syndrome components in patients with Cushing’s disease.


	Univariate model		Multivariate model 1		Multivariate model 2
	OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value

Age	1.001 (0.982–1.020)	0.915	1.002 (0.978–1.028)	0.850	0.985 (0.957–1.014)	0.319
BMI	1.228 (1.189–1.395)	<0.001	1.315 (1.197–1.444)	<0.001	1.313 (1.192–1.447)	<0.001
Sex	1.794 (1.010–3.177)	0.045	2.705 (1.229–5.955)	0.013	2.227 (0.986–5.033)	0.054
Diabetes/IGT	1.340 (0.812–2.208)	0.252	—	—	1.343 (0.666–2.706)	0.410
Hypertension	2.444 (1.321–4.522)	0.004	—	—	2.610 (1.114–6.116)	0.027
Hyperlipidemia	2.283 (1.357–3.842)	0.002	—	—	1.661 (0.836–3.300)	0.147
Central hypothyroidism	0.611 (0.321–1.161)	0.132	—	—	—	—
Cortisol	0.994 (0.973–1.015)	0.574	0.995 (0.963–1.028)	0.755	0.988 (0.955–1.022)	0.470
24 h UFC^#	1.000 (1.000–1.000)	0.525	1.000 (1.000–1.000)	0.462	1.000 (1.000–1.000)	0.409
TSH^#	1.101 (0.871–1.394)	0.421	1.284 (0.842–1.959)	0.245	1.260 (0.820–1.938)	0.292
TT4	1.001 (0.990–1.013)	0.854	1.025 (0.997–1.054)	0.078	1.026 (0.997–1.055)	0.077
TT3	1.306 (0.765–2.230)	0.329	1.021 (0.209–4.993)	0.980	1.132 (0.222–5.766)	0.881
FT4	0.974 (0.896–1.058)	0.055	0.782 (0.647–0.946)	0.011	0.770 (0.633–0.937)	0.009
FT3	1.042 (0.806–1.346)	0.756	0.658 (0.332–1.305)	0.231	0.654 (0.330–1.298)	0.225

Multivariate model 1: The logistic regression analysis included age, BMI, sex, cortisol, 24h UFC, TSH, TT4, TT3, FT4, and FT3. Multivariate model 2: The logistic regression analysis included age, BMI, sex, diabetes/IGT, hypertension, hyperlipidemia, cortisol, 24h UFC, TSH, TT4, TT3, FT4, and FT3. BMI: body mass index; IGT: impaired glucose tolerance; 24 h UFC: 24 hours urine cortisol; TSH: thyroid stimulating hormone; TT4: total thyroxine; TT3: total triiodothyronine; FT4: free thyroxine; FT3: free triiodothyronine. P value < 0.05 is shown in bold.