MAFLD in Patients with Cushing’s Disease Is Negatively Associated with Low Free Thyroxine Levels Rather than with Cortisol or TSH Levels
Table 3
Multivariate logistic regression analyses the associations of quartiles of thyroid hormones and MAFLD in patients with Cushing’s disease.
Multivariate model
OR (95% CI)
value
Age
0.990 (0.963–1.018)
0.496
BMI
1.316 (1.199–1.446)
<0.001
Sex
1.751 (0.810–3.783)
0.154
Cortisol
0.988 (0.958–1.019)
0.452
24 h UFC
2.465 (1.130–5.381)
0.453
Diabetes/IGT
1.753 (0.931–3.301)
0.082
Hypertension
2.610 (1.116–6.062)
0.027
Hyperlipidemia
1.016 (0.994–1.039)
0.160
TSH quartiles
0.248#
Q1
Ref
—
Q2
0.551 (0.199–1.522)
0.250
Q3
1.413 (0.552–3.615)
0.471
Q4
1.181 (0.423–3.298)
0.751
TT4 quartiles
0.202#
Q1
Ref
—
Q2
0.856 (0.307–2.389)
0.767
Q3
2.411 (0.764–7.608)
0.133
Q4
2.376 (0.568–9.940)
0.236
TT3 quartiles
0.999#
Q1
Ref
—
Q2
1.054 (0.366–3.034)
0.992
Q3
1.013 (0.274–3.745)
0.985
Q4
0.986 (0.187–5.180)
0.986
FT4 quartiles
0.018 #
Q1
Ref
—
Q2
0.945 (0.362–2.466)
0.908
Q3
0.257 (0.089–0.742)
0.012
Q4
0.220 (0.059–0.824)
0.025
FT3 quartiles
0.556#
Q1
Ref
—
Q2
0.541 (0.195–0.502)
0.239
Q3
0.796 (0.242–2.624)
0.708
Q4
0.470 (0.099–2.226)
0.341
BMI: body mass index; IGT: impaired glucose tolerance; 24 h UFC: 24 hours urine cortisol; TSH: thyroid stimulating hormone; TT4: total thyroxine; TT3: total triiodothyronine; FT4: free thyroxine; FT3: free triiodothyronine. #p-value for trend. P value < 0.05 is shown in bold.
