Sildenafil Enhances the Therapeutic Effect of Islet Transplantation for Diabetic Peripheral Neuropathy via mTOR/S6K1 Pathway

Figure 1

Establishment of the diabetes model, evaluation of donor islet activity, and effect of islet transplantation. (a) The body weight and blood glucose of mice in each group during the whole experiment. (b) Islets extracted from the pancreas of healthy donor mice. (c) Islet transplantation under the renal capsule (Scale = 200 μm). (d) FDA-PI staining used to detect the activity of isolated islets during culture (scale = 200 μm). (e) The results of HE staining (A) and insulin antibody immunohistochemical staining (B) of the kidney after islet transplantation in mice (immunohistochemical staining: ×200).