Sildenafil Enhances the Therapeutic Effect of Islet Transplantation for Diabetic Peripheral Neuropathy via mTOR/S6K1 Pathway

<div>Effects of sildenafil combined with islets on mTOR/S6K1 phosphorylation and expression of BDNF and MBP proteins in RSC96 cells under high glucose conditions. (a, b) The level and semiquantitative analysis of mTOR/S6K1 total protein and phosphorylated protein in RSC96 cells cocultured with sildenafil and islets under high glucose condition. (c, d) The level and semiquantitative analysis of BDNF and MBP proteins in RSC96 cells cocultured with sildenafil and islets under the condition of high glucose. 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International Journal of Endocrinology

fig5

Figure 5

Figure 5: Sildenafil Enhances the Therapeutic Effect of Islet Transplantation for Diabetic Peripheral Neuropathy via mTOR/S6K1 Pathway 