Dulaglutide Protects Mice against Diabetic Sarcopenia-Mediated Muscle Injury by Inhibiting Inflammation and Regulating the Differentiation of Myoblasts

Figure 5

Expression of myostatin, PGC-1α, and FNDC5 in C2C12 cells treated with different glucose concentrations. (a) C2C12 cells were induced to differentiate and then treated with different glucose concentrations for 24 h. The C2C12 protein was extracted, and the expression levels of myostatin, FNDC5, and PGC-1α proteins were detected. (b) The Image J software was used to analyze the gray value of proteins after the stimulation of C2C12 cells with high glucose concentrations, and statistical analysis was performed.  < 0.05,  < 0.01,  < 0.001, comparison between the high glucose concentration group and the normal group.

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(b)