Causal Relationships between Homocysteine and the Polycystic Ovary Syndrome: A Mendelian Randomization Analysis

Table 2

Weighted median and MR-Egger analysis for genetic associations between exposures and PCOS risk.

Method	Weighted median	MR-egger		MR-PRESSO	Steiger test
		Estimate	Intercept		Direction
FinnGen					True
Estimate (95% CI)	0.362 (−0.227, 0.951)	0.630 (−0.406, 1.666)	−0.040 (−0.116, 0.036)
value	0.228	0.233	0.300	0.118
Tyrmi et al.					True
Estimate (95% CI)	−0.015 (−0.284, 0.253)	0.044 (−0.394, 0.483)	−0.005 (−0.037, 0.028)
value	0.912	0.843	0.780	0.646
Day et al.					True
Estimate (95% CI)	0.090 (−0.254, 0.434)	0.384 (−0.279, 1.048)	−0.024 (−0.072, 0.024)
value	0.608	0.256	0.332	0.181