The Influence of 3′UTRs on MicroRNA Function Inferred from Human SNP Data
Figure 3
Comparison of SNP density, DAF, and MAF between different regions of miRNA target genes and non-miRNA target genes. SNPs on miRNA target sequences were separated into (1) seed target region: region matching the 5′ end of the miRNA; (2) excluding seed target region: all the rest of 3′UTRs without seed target region; (3) window regions: regions surrounding the 5′ end of the miRNA target site defined in this study, 67 nucleotides for SNP density, 28 nucleotides for DAF, and 26 nucleotides for MAF; (4) excluding the window regions: all the rest of 3′UTRs without the corresponding window regions. SNPs from these defined regions were compared to the SNPs from non-miRNA target genes. (a) All 4 regions from miRNA target sequences have lower SNP density than non-miRNA target genes. (b) All 4 regions from miRNA target sequences have higher fraction of DAF than non-miRNA target genes. (c) All 4 regions from miRNA target sequences have higher fraction of MAF than non-miRNA target genes. Also shown are the Wilcoxon rank sum test P-values comparing to non-miRNA target genes.
