Human Genomic Deletions Generated by SVA-Associated Events

Figure 1

SRAD and SIMD in the human genome. This figure shows the mechanisms underlying SRAD and SIMD in the human genome. (a) SRAD event. In the illustration of the chimpanzee, Alu and SVA elements are intact but only one chimeric element exists in the illustration of human-specific SRAD. For both illustrations, two arrows indicate the positions where each PCR primer anneals. (b) SIMD event. This illustration depicts the insertion of the SVA element and the deletion of genomic DNA (blue box).