Polymorphisms of Leptin (-2548 G/A) and Leptin Receptor (Q223R) Genes in Iranian Women with Breast Cancer

Table 2

Final results of -2548 G/A LEP and Q223R LEPR polymorphisms in the two groups of patients and controls with the risk of breast cancer.

Genotypes	Controls; = 41; (%)	Patients; = 45; (%)	Odds ratio	95% confidence interval	value
LEP (-2548) G/A
GG	5 (12.2)	7 (15.6)	1
GA	19 (46.3)	11 (24.4)	0.41	(0.1–1.62)	0.2
AA	17 (41.5)	27 (60)	1.13	(0.3–4.15)	0.8
Alleles
G-allele	29 (35.4)	25 (27.8)
A-allele	53 (64.6)	65 (72.2)	1.35	(0.74–2.44)	0.33
LEPR Q223R
QQ	17 (41.5)	19 (42.2)
QR	18 (43.9)	25 (55.6)	8.3	(0.92–75.36)	0.06
RR	6 (14.6)	1 (2.2)	6.7	(0.73–61.5)	0.09
Alleles
Q-allele	52 (63.4)	63 (70)
R-allele	30 (36.3)	27 (30)	0.71	(0.36–1.41)	0.33

Reference group.