Polymorphisms of Leptin (-2548 G/A) and Leptin Receptor (Q223R) Genes in Iranian Women with Breast Cancer

Table 4

Relationship between -2548 G/A LEP and Q223R LEPR polymorphisms with pathological indicators in patients with breast cancer.

Pathological feature	Number of patients (%)		value
LEP (-2548) G/A	GA + AA	GG
ER
Negative	12 (92.3)	1 (7.7)	0.65
Positive	26 (81.3)	6 (18.8)
PR
Negative	13 (86.7)	2 (13.3)	1.00
Positive	25 (83.3)	5 (16.7)
HER2
Negative	27 (90)	3 (10)	0.19
Positive	11 (73.3)	4 (26.7)
Stage
I & II	21 (91.3)	2 (8.7)	0.24
III & IV	17 (72.28)	5 (22.73)
LEPR Q223R	QR + RR	QQ
ER
Negative	4 (30.8)	9 (69.2)	0.5
Positive	15 (46.9)	17 (56.7)
PR
Negative	6 (40)	9 (60)	1.00
Positive	25 (83.3)	17 (56.7)
HER2
Negative	14 (46.7)	16 (53.3)	0.5
Positive	5 (33.3)	10 (66.7)
Stage
I & II	10 (43.4)	13 (56.5)	1.00
III & IV	9 (41)	13 (59)

Numbers in parentheses represent the percentage.